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Analgesic activity of Justicia beddomei leaf extract

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Journal name: Ancient Science of Life
Original article title: Analgesic activity of Justicia beddomei leaf extract
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:

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Author:

U. Srinivasa, J. Venkateshwara Rao, A.M. Krupanidhi, S. Shanmukhappa


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Analgesic activity of Justicia beddomei leaf extract

Year: 2007

Copyright (license): CC BY-NC-SA


Download the PDF file of the original publication


Summary of article contents:

Introduction

Justicia beddomei, a member of the Acanthaceae family, is a glabrous shrub that thrives in moist, shaded areas, particularly in Kerala, India. The leaves of this plant are traditionally recognized for their medicinal properties, including being diuretic, antispasmodic, expectorant, and anti-asthmatic, among others. Despite the documented uses in traditional medicine, there has been a lack of systematic investigation into its phytochemical composition and analgesic properties. This study aims to evaluate the analgesic activity of ethanolic extracts from the leaves of Justicia beddomei, comparing its effects to the standard analgesic, morphine sulfate.

Analgesic Activity and Phytochemical Composition

The study employs Eddy’s hot plate method to assess analgesic activity in albino rats administered ethanolic extracts of Justicia beddomei at doses of 50 mg/kg and 100 mg/kg. Results indicated that significant analgesic activity occurred at 90 minutes post-administration, with effects comparable to morphine sulfate, suggesting a potential for its use in pain management. Phytochemical analyses revealed the presence of alkaloids, tannins, and reducing sugars in the extracts, contributing to the observed analgesic effects. This finding underlines the necessity for further research to identify and characterize the specific chemical constituents responsible for these effects, as the exact mode of action remains unexplored in existing literature.

Conclusion

The findings from this study demonstrate the significant analgesic properties of the ethanolic extract of Justicia beddomei leaves, affirming its potential as a natural analgesic agent. The preliminary phytochemical screening indicates that various constituents may contribute to this activity, warranting deeper investigation into the plant's bioactive components. As traditional medicine continues to inform contemporary practices, elucidating the pharmacological properties of plants like Justicia beddomei is essential for integrating such treatments into modern therapeutic approaches. Future studies should aim to clarify the specific mechanisms of action and further validate the efficacy of this extract compared to conventional analgesics.

FAQ section (important questions/answers):

What is the focus of the study on Justicia beddomei?

The study evaluates the analgesic activity of the ethanolic extract of Justicia beddomei leaves using albino rats and compares its effects to morphine sulfate.

How was the ethanolic extract of Justicia beddomei prepared?

The leaves were shade dried, coarsely powdered, and extracted using successive solvents in ascending order of polarity, primarily focusing on ethanol.

What were the key findings regarding analgesic activity?

Ethanolic extract showed significant analgesic activity at 90 minutes post-administration, but it was less effective than morphine sulfate, indicating a potential for further study.

What phytochemical constituents were found in the extract?

Preliminary analysis revealed the presence of alkaloids, carbohydrates, and tannins in the ethanolic extract, which may be responsible for its analgesic properties.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Analgesic activity of Justicia beddomei leaf extractâ€�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Activity:
Activity refers to the capacity of a substance, such as the ethanolic extract of Justicia beddomei, to produce a specific effect, particularly in context to analgesic effects on pain. The term often embodies various forms of physiological responses that can be measured through experimental analysis, typically in pharmacological studies.

2) Drug:
Drug denotes any substance used for medical purposes, including analysis of analgesic properties in the study. In this context, morphine sulphate is referenced as a standard drug for pain relief comparisons against extracts. The term encompasses pharmaceuticals, natural extracts, and synthetics used to treat or manage conditions.

3) Water:
Water is highlighted as a solvent in the methodology of extracting phytochemicals from Justicia beddomei leaves. It represents a crucial element in pharmaceutical processes, often used for dissolving substances, thus enabling the extraction of bioactive compounds essential for subsequent analyses in pharmacological studies.

4) Phytochemical:
Phytochemical refers to the bioactive compounds found in plants, such as alkaloids and tannins identified in Justicia beddomei. Understanding phytochemicals is essential in pharmacognosy and pharmacology, as they are the basis for assessing therapeutic benefits and potential medicinal properties of plant extracts and their use in treatments.

5) Pharmacology:
Pharmacology is the scientific study of drugs and their effects on living organisms. This includes understanding analgesic properties and mechanisms of action of substances, such as the Justicia beddomei extract versus morphine. It forms the foundation for drug development and therapeutic usage in clinical settings.

6) Discussion:
Discussion is a critical section of a research paper, where findings, such as the analgesic activity of plant extracts, are interpreted and contextualized within existing literature. It encourages insight into implications, further research directions, and the significance of the study's outcomes, facilitating scientific discourse.

7) Flavonoid:
Flavonoid represents a class of phytochemicals known for their antioxidant capabilities, though not explicitly found in the Justice beddomei extract according to this study. They play a vital role in medicinal chemistry and dietary health, with implications for disease prevention and therapeutic effects within botanical studies.

8) Medicine:
Medicine encompasses a branch of science focused on diagnosing, treating, and preventing illnesses. The study of Justicia beddomei’s analgesic properties ties into traditional and modern medicinal practices. Understanding how natural medicines interact with biological systems is crucial for effective treatment and patient care.

9) Science (Scientific):
Science represents the systematic study of the structure and behavior of the physical and natural world through observation and experimentation. This research reflects scientific inquiry, combining methods from pharmacognosy and pharmacology to investigate plant properties, establishing a basis for future developments in medicinal therapies.

10) Vijaya (Vijayā):
Vijaya is mentioned as part of the author’s name, contributing to the scientific research surrounding the medicinal properties of Justice beddomei. Authors play a key role in peer-reviewed studies, ensuring credibility, communication of findings, and advancement of knowledge within their respective fields of study.

11) Mishra (Miśra):
Mishra is another author referenced in the research article, highlighting the collaborative nature of scientific investigation. Author contributions are vital in developing comprehensive studies, combining multiple expertise to enhance the understanding of plant properties and their potential medicinal applications across various disciplines.

12) Botany:
Botany is the study of plants, including their physiology, structure, and development. This study emphasizes the importance of botanical knowledge in identifying and utilizing plant species like Justicia beddomei for medicinal purposes. Botany is fundamentally intertwined with pharmacognosy and traditional medicine systems.

13) Sugar:
Sugar, representing a form of carbohydrate, was detected in the phytochemical analysis of Justicia beddomei leaves. Carbohydrates, including simple sugars, can serve various biological functions, including energy provision and potential roles in pharmacological activities, thereby making their identification significant in plant studies.

14) Blood:
Blood is crucial in the context of medicinal properties associated with Justicia beddomei. The leaves are suggested for ailments involving blood components, such as haemoptysis. Understanding blood-related conditions assists in utilizing medicinal plants effectively, emphasizing their relevance in treating systemic health issues.

15) Diet:
Diet encompasses the food and drink choices influencing health and wellness. The study mentions the dietary management of animals used in experiments, indicating the importance of a controlled diet in scientific research. Proper diet ensures the validity of experimental results and reflects wider implications for nutrition and health.

Other Science Concepts:

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Discover the significance of concepts within the article: �Analgesic activity of Justicia beddomei leaf extract�. Further sources in the context of Science might help you critically compare this page with similair documents:

Statistical analysis, Analgesic activity, Traditional System of Medicine, Solvent extraction, Preliminary phytochemical analysis, Healthy Wistar albino rats, Chemical constituent, Eddy's hot plate method, Significant analgesic activity, Qualitative Investigation, Institutional animal's ethical committee.

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