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Transdermal Diffusion Studies of a Polyherbal Ointment and its tropical therapy

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Journal name: Ancient Science of Life
Original article title: Transdermal Diffusion Studies of a Polyherbal Ointment and its tropical therapy
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

C. Sreenivas Reddy, T. Rammohan, N. Madhu, M.C. Divaker


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Transdermal Diffusion Studies of a Polyherbal Ointment and its tropical therapy

Year: 1999

Copyright (license): CC BY-NC-SA


Download the PDF file of the original publication


Summary of article contents:

Introduction

The study investigates the transdermal diffusion properties of a polyherbal ointment using Franz diffusion cells and microbial zone inhibition as parameters for drug release. The research aimed to evaluate the effectiveness of three different ointment bases: Hydrocarbon Base (HB), Surfactant Base (SB), and Surfactant Base with Penetration Enhancer (SBPE) containing 10% DMSO. Results indicated that the SBPE formulation exhibited the highest drug release capacity, which correlates with its clinical efficacy in treating various skin infections, yielding an overall cure rate of 79.3%.

Efficacy of the Surfactant Base with Penetration Enhancer

The Surfactant Base with Penetration Enhancer (SBPE) formulation showed significant drug release capabilities compared to the other bases. The permeation-enhanced ointment facilitated better transdermal absorption, as demonstrated by the elevated microbicidal activity against bacterial strains like Escherichia coli and Staphylococcus aureus, as well as fungal strains such as Candida albicans and Candida tropicalis. The efficiency of SBPE was further verified through high-performance liquid chromatography (HPLC) analyses and microbial inhibition studies, indicating that the incorporation of DMSO substantially improves the ointment's antimicrobial properties and effectiveness in treating infected wounds, scratches, scabies, pyoderma, and furunculosis.

Conclusion

The findings of this research highlight the promising potential of polyherbal ointments, particularly formulations incorporating penetration enhancers, as effective topical therapeutics for managing various skin infections. The utilization of advanced analytical techniques like HPLC alongside microbial zone inhibition tests offers a comprehensive approach to evaluating the efficacy of these formulations. The successful clinical outcomes observed in patients underscore the viability of SBPE as a therapeutic option, with an overall success rate of 79.33%, reaffirming the value of polyherbal products in contemporary medicinal applications.

FAQ section (important questions/answers):

What was the primary goal of the transdermal diffusion studies?

The primary goal was to evaluate a polyherbal ointment’s drug release and antimicrobial efficacy using HPLC and microbial zone inhibition as monitoring parameters.

What are the main ingredients used in the polyherbal ointment?

The formulation included Nigella sativa, Rubia cordifolia, Pongamia glabra, Mallotus philippinensis, and Psoralea corylifolia, chosen for their reported antimicrobial properties.

What was the overall cure rate for the ointment in clinical trials?

The overall cure rate for the polyherbal antimicrobial ointment was 79.33%, indicating it was effective for various infected skin conditions.

How did the different ointment bases perform in drug release?

The surfactant base with penetration enhancer (SBPE) showed the highest drug release, followed by the surfactant base (SB) and then the hydrocarbon base (HB), which had the lowest release rate.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Transdermal Diffusion Studies of a Polyherbal Ointment and its tropical therapyâ€�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
The term 'Drug' in this context refers to the active pharmaceutical substances derived from plants, specifically in the polyherbal ointment studied. It signifies the components responsible for therapeutic effects, particularly antimicrobial activity, and is a central focus of both pharmacological studies and clinical evaluations conducted in the research.

2) Activity:
In the study, 'Activity' indicates the therapeutic potential of the herbal formulation, particularly its ability to inhibit the growth of microorganisms. This reflects the effectiveness of the ointment's constituents in treating infections and skin conditions, which is critical for assessing the overall efficacy and safety of the treatment.

3) Rubia cordifolia:
Rubia cordifolia, commonly known as Indian Madder, is one of the crude drugs used in the formulation of the polyherbal ointment. Its inclusion is based on its reputed antimicrobial properties, which contribute to the ointment’s effectiveness against various skin infections, thus validating its role in traditional medicine.

4) Quality:
The term 'Quality' underscores the importance of standardization in the preparation of herbal remedies. It refers to the assessment and assurance that the herbal ointment meets specific pharmacopoeial standards, ensuring that the active ingredients are effective and safe for therapeutic use in clinical settings.

5) Water:
In the context of the study, 'Water' is primarily used as a solvent for various extraction methods of the crude drugs. It serves as a medium for the diffusion studies, and maintaining pH and temperature control is crucial for accurate measurement of drug release and efficacy during the experiments.

6) Pharmacological:
The term 'Pharmacological' relates to the study of the effects of the ointment’s drugs on biological systems. The pharmacological assessment evaluates how the active ingredients work synergistically to display antimicrobial properties, which is fundamental to understanding the ointment's therapeutic mechanisms and potential side effects.

7) Phytochemical:
Phytochemical refers to the chemical compounds derived from plants present in the herbal ointment. This term is significant as it highlights the role of these bioactive constituents in providing therapeutic benefits, necessitating their identification and quantification to ascertain the ointment’s efficacy and safety profile.

8) Inflammation:
'Inflammation' is a clinical indicator associated with skin conditions assessed in the study, such as infections and irritations. By monitoring inflammation, researchers can evaluate the ointment's effectiveness in alleviating symptoms, which is critical for determining the overall success rate of the treatment in patients.

9) Discussion:
'Discussion' in the context of this study refers to the section where the results are analyzed and interpreted. It is critical for contextualizing findings, comparing them against existing literature, and determining the implications of the study outcomes for future research and clinical applications in herbal medicines.

10) Irritation:
'Irritation' points to potential adverse effects observed during the topical application of the ointment. This term is relevant in evaluating the safety of the formulation, as assessing irritation levels is essential to ensure that the treatment does not cause harm or discomfort to patients during therapy.

11) Substance:
'Substance' refers to the individual chemical compounds and active ingredients found within the herbal formulation. In the context of pharmacological studies, understanding the substances involved is vital for analyzing their interactions, effects, and overall contributions to the ointment's therapeutic efficacy.

12) Science (Scientific):
'Science' denotes the systematic study of the herbal formulation through controlled experiments and analysis. This underscores the rigorous methodologies employed in the research, highlighting the significance of evidence-based approaches in advancing traditional herbal medicine into modern pharmacotherapeutic practices.

13) Madhu:
'Madhu' refers to co-author N. Madhu, whose contribution is pivotal in the research being conducted. Authors create a collective knowledge base through collaboration, and each member’s expertise contributes to the study's depth, aiding in the interpretation of complex results associated with herbal formulations.

14) Ravi (Rāvī, Rāvin, Ravin):
'Ravi' relates to Prof. T.K. Ravi, who provided support and guidance throughout the research process. Acknowledging contributions from experienced mentors reflects the collaborative nature of scientific studies, emphasizing the importance of academic leadership in facilitating research activities and fostering innovative approaches.

15) Hand:
'Hand' refers to the application of the ointment on the skin, which involves manual handling during topical administration. It encapsulates the human element of the study, focusing on practical application and user experience, essential for gauging real-world efficacy and patient adherence to treatment protocols.

Other Science Concepts:

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Discover the significance of concepts within the article: �Transdermal Diffusion Studies of a Polyherbal Ointment and its tropical therapy�. Further sources in the context of Science might help you critically compare this page with similair documents:

High performance liquid chromatography, Phytochemical analysis, Antimicrobial activity, Zone of inhibition, Topical sensitivity test, Clinical observation, Pharmacognosy, Clinical success rate, Bacterial strain, Crude drug, Microbial contamination test, Equilibrium conditions, Penetration enhancer, Polyherbal ointment, Chemical markers, Herbal drug industry.

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