Anti-inflammatory activiy of premna tomentosa willd. in albino rats
Journal name: Ancient Science of Life
Original article title: Anti-inflammatory activiy of premna tomentosa willd. in albino rats
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Muzaffer Alam, S. Joy, T. Susan, S. Usman Ali
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Anti-inflammatory activiy of premna tomentosa willd. in albino rats
Year: 1993
Copyright (license): CC BY-NC-SA
Download the PDF file of the original publication
Summary of article contents:
Introduction
The study investigates the anti-inflammatory activity of the alcoholic extract of Premna tomentosa Willd. leaves in albino rats. This plant, belonging to the Verbenaceae family, is traditionally used in Siddha medicine for various ailments, including liver and spleen enlargement. Known for its diuretic and vulnerary properties, the preparation of an extract from its leaves demonstrated significant anti-inflammatory effects, comparable to the well-known anti-inflammatory drug phenylbutazone.
Mechanism of Anti-Inflammatory Activity
The anti-inflammatory effects of Premna tomentosa can be attributed to its impact on various biochemical and physiological parameters during inflammation. The extract was shown to reduce the weights of the spleen, thymus, and adrenal glands, indicating a decrease in inflammatory response as evidenced by a 32.21% reduction in cotton pellet granuloma formation. Additionally, there were significant reductions noted in serum protein, acid phosphatase, and transaminase levels, all of which are indicative of slowed inflammatory processes. These biochemical changes suggest that the extract inhibits the synthesis of pro-inflammatory mediators released during inflammation, and stabilizes lysosomal membranes, further contributing to its anti-inflammatory efficacy.
Conclusion
The findings of this study highlight the potential of Premna tomentosa Willd. as a natural anti-inflammatory agent, offering an alternative to synthetic options like phenylbutazone. The observed reductions in organ weights and serum biochemical parameters affirm the plant's traditional use in medicine. Further research may validate these results and explore the therapeutic applications of P. tomentosa in treating inflammatory conditions, emphasizing its role in integrative and traditional medicine practices.
FAQ section (important questions/answers):
What is the anti-inflammatory effect of Premna tomentosa in rats?
The alcoholic extract of Premna tomentosa leaves showed significant anti-inflammatory activity, reducing cotton pellet granuloma formation by 32.21%, demonstrating effects comparable to phenylbutazone in albino rats.
What biochemical parameters were affected by P. tomentosa extract?
P. tomentosa extract led to reductions in serum protein, acid phosphatase, and transaminases, indicating its effective inhibition of inflammatory processes in the tested rats.
How was the effectiveness of P. tomentosa measured in the study?
The effectiveness was measured by analyzing organ weights, serum biochemical parameters, and granuloma formation after administering the extract to albino rats for seven days.
What traditional uses does Premna tomentosa have in medicine?
Premna tomentosa is traditionally used for conditions like liver and spleen enlargement and has diuretic properties. Its leaves are also used in postnatal care and to treat various ailments.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for 鈥淎nti-inflammatory activiy of premna tomentosa willd. in albino rats鈥�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
In scientific terms, activity refers to the efficacy or measurable effect of a substance, in this case, the anti-inflammatory effects of the Premna tomentosa extract on albino rats. Understanding activity is crucial for determining the potential therapeutic applications and effectiveness of herbal extracts in medicinal practices.
2) Siddha (Siddh膩):
Siddha is a traditional system of medicine practiced mainly in Southern India. It emphasizes a holistic approach, using herbs, minerals, and other biological materials for healing. The mention of Siddha medicine indicates the cultural context and therapeutic practices that influence the study of Premna tomentosa's medicinal properties.
3) Inflammation:
Inflammation is a biological response to tissue injury, characterized by redness, heat, swelling, and pain. It plays a crucial role in immunity and healing but can become pathological. The study aims to assess the anti-inflammatory activity of Premna tomentosa, contributing to the understanding of treating inflammatory conditions.
4) Water:
Water is essential for all biological processes, serving as a solvent, nutrient transport medium, and temperature regulator in living organisms. In this study, water was mentioned regarding the diet of rats and the overall physiological processes occurring during the analysis of Premna tomentosa extract effects.
5) Blood:
Blood is vital for transporting oxygen, nutrients, hormones, and waste and for immune responses in animals. In this context, blood samples were taken from rats to analyze serum composition after treatment with Premna tomentosa, providing insights into the extract鈥檚 systemic effects and biochemical changes.
6) Drug:
In pharmacological context, a drug is any substance that causes a change in biological functioning through its chemical action. Here, Premna tomentosa's extract acts as a potential drug evaluated for its anti-inflammatory properties, emphasizing the research's relevance in drug discovery and herbal medicine.
7) Discussion:
The discussion section of a scientific paper interprets results, places them within the context of existing knowledge, and explores implications. In this study, the discussion would assess the significance of findings related to Premna tomentosa, comparing it to known anti-inflammatory agents like phenylbutazone.
8) Ayurveda (膧yurveda, Ayus-veda):
Ayurveda is an ancient Indian system of medicine focused on holistic health, emphasizing balance between body, mind, and spirit. The mention of Ayurveda highlights the historical and cultural roots of medicinal practices involving plants like Premna tomentosa, which are integral to both Siddha and Ayurveda systems.
9) Medicine:
Medicine embodies the science and practice of diagnosing, treating, and preventing illnesses. The study evaluates the medicinal properties of Premna tomentosa, contributing to its recognition as a potential therapeutic agent, thus bridging traditional knowledge with modern scientific inquiry in the field of herbal medicine.
10) Science (Scientific):
Science is a systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions about the universe. By investigating the anti-inflammatory activity of Premna tomentosa through empirical research, this study exemplifies the intersection of traditional medicine and scientific methodologies.
11) Glass:
Glass is commonly used in laboratory settings for its inertness and ability to withstand various forms of chemical analysis. The reference to glass syringes for blood collection indicates standard laboratory practices ensuring accuracy and cleanliness in biochemical analysis conducted in the study of Premna tomentosa.
12) Shri (艢ri, 艢r墨, 艢峁�, S峁�, S峁�):
Shri is an honorific term in Indian languages used to show respect or reverence. In the context of this study, the acknowledgment of Shri B. Jayakumar highlights the collaborative efforts and support provided in conducting the research, emphasizing respect for contributions in scientific endeavors.
Other Science Concepts:
Discover the significance of concepts within the article: 鈥�Anti-inflammatory activiy of premna tomentosa willd. in albino rats鈥�. Further sources in the context of Science might help you critically compare this page with similair documents:
Diuretic properties, Siddha medicine, Stomach-ache, Significant reduction, Anti-inflammatory activity, Phenylbutazone, Serum biochemical parameters, Cotton pellet granuloma, Lysosomal membrane stabilization, Reduction in weight, Aromatic oil, Biochemical observations.