STUDY OF KUSTHA (SAUSSUREA LAPPA, Clarke) IN ISCHAEMIC HEART DISEASE
Journal name: Ancient Science of Life
Original article title: STUDY OF KUSTHA (SAUSSUREA LAPPA, Clarke) IN ISCHAEMIC HEART DISEASE
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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O.P. Upadhyay, J.K. Ojha, H.S. Bajpai, A.K. Hathwal
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: STUDY OF KUSTHA (SAUSSUREA LAPPA, Clarke) IN ISCHAEMIC HEART DISEASE
Year: 1993
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
The study presented in this article investigates the effectiveness of the herbal drug Kushtha (Saussurea lappa) in treating Ischaemic Heart Disease (IHD), particularly among diabetic patients. IHD, one of the leading causes of death in modern society, is frequently linked to diabetes and atherosclerosis. The objective of this research was to explore a safe and reliable herbal treatment option to help manage IHD, given the increasing rates of the disease and the prevalence of associated conditions such as diabetes. Recognizing the historical context of Kushtha in Indian medicine, this study aims to validate its purported health benefits, which include antimicrobial and antidiabetic properties, while also comparing its efficacy to a conventional vasodilator drug, Segontin (Prenylamine lactate).
Efficacy of Kushtha in Combination Therapy
The findings from the clinical trial demonstrated that the combination of Kushtha and Segontin yields significant benefits for patients with IHD compared to either treatment alone. Patients treated with Kushtha alone exhibited moderate to no response, whereas those receiving the combination treatment showed a substantial improvement in clinical symptoms, laboratory data, and electrocardiogram (ECG) results. Notably, 80% of patients in the combined treatment group experienced significant changes in their ECG recordings, which reverted to near-normal levels, unlike the group receiving Segontin alone, which had lesser improvements. Furthermore, the side effects observed were considerably milder in the combined group, allowing for a reduction in the dosage of Segontin, highlighting the potential for Kushtha to enhance treatment efficacy while minimizing adverse effects.
Conclusion
This study indicates that Kushtha (Saussurea lappa) is a promising herbal remedy that can be effectively integrated into the treatment regimen for patients suffering from Ischaemic Heart Disease, especially those with diabetes. The research called attention to the significant improvement in both clinical and biochemical parameters when Kushtha was used in combination with Segontin, underscoring its therapeutic potential. The findings suggest that Kushtha not only mitigates the symptoms of IHD but also influences lipid levels positively, thus contributing to improved coronary circulation and myocardial function. This preliminary evidence supports further research into Kushtha's role in cardiovascular health and may pave the way for more integrative approaches to managing chronic conditions like IHD.
FAQ section (important questions/answers):
What is the purpose of the study on Saussurea lappa?
The study aimed to evaluate the effectiveness of Saussurea lappa, known as Kushtha, in treating ischemic heart disease (IHD), particularly in diabetic patients, and how it compares with a known vasodilator, Segontin.
How were the study participants selected?
Forty-five patients attending the diabetic clinic with diagnoses of IHD were included. They were divided into three groups for treatment with Kushtha alone, Kushtha with Segontin, and Segontin alone, based on clinical evaluations.
What were the significant findings regarding serum cholesterol levels?
After four months of treatment, both Kushtha and Kushtha + Segontin significantly reduced serum cholesterol levels. The Kushtha + Segontin group showed the most significant reduction, indicating a beneficial effect on lipid profiles.
What side effects were observed during the study?
The study noted various side effects in the Segontin group, including gastrointestinal disturbances and headache. In contrast, the combined Kushtha group displayed minimal side effects, suggesting improved tolerability with the combination therapy.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “STUDY OF KUSTHA (SAUSSUREA LAPPA, Clarke) IN ISCHAEMIC HEART DISEASE�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Kushtha (Kuá¹£á¹ha):
Kustha is another term for Kushtha, referring to the same herbal drug derived from Saussurea lappa. It is recognized in traditional Indian medicine for its medicinal properties, particularly in treating conditions involving metabolism and cardiovascular health, making it relevant in this clinical study.
2) Drug:
In this context, the term 'drug' signifies any substance utilized for therapeutic purposes. Specifically, the herbal drug Kushtha and the pharmaceutical drug Segontin were examined to evaluate their effectiveness in treating IHD and their influence on biochemical parameters related to heart health.
3) Depression:
Depression in this study refers specifically to ST segment depression observed in electrocardiograms (ECGs) of patients with Ischaemic Heart Disease (IHD). This ECG finding is crucial as it indicates myocardial ischemia, a condition where the blood flow to the heart is inadequate, requiring effective treatment.
4) Saussurea lappa:
Saussurea lappa, also known as Kushtha, is a flowering plant used in traditional Ayurvedic medicine. Its significance in the study lies in its potential health benefits, particularly in improving cardiovascular function and managing conditions like diabetes and hyperlipidemia, pivotal in treating IHD.
5) Science (Scientific):
Science refers to the systematic study aimed at understanding phenomena through observation and experimentation. This clinical study utilizes scientific methods to explore the efficacy of Kushtha and Segontin in treating IHD, demonstrating an intersection of traditional herbal remedies and modern medical research.
6) Medicine:
Medicine encompasses the practices and substances used to diagnose, treat, and prevent illnesses. The research on Kushtha as a treatment for Ischaemic Heart Disease showcases the integration of traditional and modern approaches in medicine, aiming for improved patient outcomes through effective therapies.
7) Antibiotic (Antibacterial):
The term antibacterial indicates a property of certain substances that inhibit bacterial growth. In the context of Kushtha, previous studies have reported its antibacterial properties, suggesting its multifaceted utility in addressing various health concerns, although this study primarily focuses on its effects on cardiovascular disease.
8) Dravyaguna (Dravyaguṇa, Dravya-guna):
Dravyaguna, a branch of Ayurveda, focuses on the study of medicinal properties of herbs and their applications in health. This field is integral to understanding how substances like Kushtha can be used in treating conditions like Ischaemic Heart Disease, aligning traditional wisdom with clinical evidence.
9) Discussion:
Discussion refers to the interpretation and analysis of the study's findings, where the results regarding Kushtha and Segontin are evaluated in relation to existing literature. It provides insight into the implications of the findings, supporting further research and potential clinical applications.
10) Ayurveda (Ä€yurveda, Ayus-veda):
Ayurveda is an ancient system of medicine originating from India, which emphasizes balance in bodily systems and uses herbal remedies. This study's focus on Kushtha highlights the importance of Ayurvedic practices and their relevance in modern medical treatments, particularly for Ischaemic Heart Disease.
11) Sugar:
In the context of the study, sugar refers to the levels of glucose in the blood, a critical parameter in assessing diabetes mellitus. Managing blood sugar levels is essential for patients with Ischaemic Heart Disease, as diabetes poses a significant risk factor for cardiovascular complications.
12) Blood:
Blood serves as a vital fluid transporting nutrients, oxygen, and waste throughout the body. The study monitored blood parameters such as sugar levels, cholesterol, and triglycerides to evaluate the effectiveness of treatments. These measures are essential indicators of cardiovascular health in patients with IHD.
13) Post:
Post refers to the timeline after treatment initiation in the clinical study, where assessments were conducted to evaluate the effectiveness of Kushtha and Segontin. Monitoring patient responses post-treatment provides crucial insights into the efficacy and safety of the therapies administered.
Other Science Concepts:
Discover the significance of concepts within the article: �STUDY OF KUSTHA (SAUSSUREA LAPPA, Clarke) IN ISCHAEMIC HEART DISEASE�. Further sources in the context of Science might help you critically compare this page with similair documents:
Age-group, Serum triglyceride, American Diabetic Association, Oral glucose tolerance test, Significant response, Serum cholesterol level, ECG changes, Side effect, Biochemical Assay, Ischaemic heart disease, Diabetic clinic, Clinical symptom, Antihistaminic agent.