Significance of Sub-acute toxicity study
A sub-acute toxicity study assesses the effects of a substance administered at lower doses over a more extended period, typically lasting 28 days. This type of study aims to identify any adverse effects that might not be evident in acute studies. It involves evaluating the toxic effects resulting from repeated exposure, allowing researchers to observe changes in health indicators, organ function, and potential toxicity accumulation. Overall, these studies provide critical safety assessments for various substances before longer-term studies.
Synonyms: Sub-chronic toxicity study
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The concept of Sub-acute toxicity study in scientific sources
Sub-acute toxicity study evaluates the longer-term safety of RCAE through repeated administration, focusing on physiological and biochemical responses. It serves as a follow-up to identify subtle reactions and ensure safety over extended periods.
From: World Journal of Pharmaceutical Research
(1) Research designed to evaluate the effects of a substance over a period longer than an acute study but shorter than a chronic study.[1] (2) A study designed to evaluate the effects of repeated exposures to a substance over a limited period, typically shorter than chronic studies.[2] (3) An investigation of the toxic effects of a substance after repeated exposure over a longer duration, typically involving periods of 28 days.[3] (4) A study that evaluates the safety and effects of the Polyherbal formulation after prolonged exposure over 28 days.[4] (5) Investigation of the effects of a drug administered over multiple days to observe changes in body weight or other parameters, specifically related to the Shatgandha formulation in the study.[5]
From: International Ayurvedic Medical Journal
(1) An evaluation of the effects of a substance after repeated doses over an extended period (28 days in this case) to determine the potential for toxicity accumulation and effects on various organs.[6] (2) A study designed to assess the effects of a substance following repeated or prolonged exposure over a period of time.[7] (3) A sub-acute toxicity study involves administering a substance to animals over a period to observe any pathological and biochemical changes.[8]
From: AYU (Journal of Research in Ayurveda)
(1) An evaluation of the longer-term safety of RCAE through repeated administration over a period, assessing physiological and biochemical parameters.[9] (2) A follow-up study to discover more subtle responses and assure safety at longer durations.[10]
From: Journal of Ayurveda and Integrative Medicine
(1) A toxicity study examining the effects of WSE administered over a period of 28 days at various doses (0, 500, 1000, 2000 mg/kg) to Wistar rats.[11]