Significance of Streptozotocin induced diabetes
Streptozotocin induced diabetes refers to a method used in laboratory settings where the compound streptozotocin is administered to induce diabetes in experimental animals, particularly rats. This chemical selectively destroys insulin-producing beta cells in the pancreas, leading to elevated blood glucose levels and mimicking aspects of diabetes mellitus. This model is widely used in research to study diabetes and its treatments, allowing scientists to explore the effects of potential therapies and better understand the disease's mechanisms.
Synonyms: Streptozotocin-induced hyperglycemia
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The concept of Streptozotocin induced diabetes in scientific sources
Streptozotocin induced diabetes is a laboratory model in rats, achieved through a single injection that damages insulin-producing beta cells, leading to elevated blood glucose levels and hyperglycemia.
From: The Malaysian Journal of Medical Sciences
(1) This is a model of diabetes in which myocyte death is dependent on angiotensin II, as mentioned in the text.[1] (2) Streptozotocin-induced diabetes refers to diabetes that is induced in experimental models through the administration of streptozotocin, which has a cytotoxic effect on pancreatic β-cells.[2] (3) A model of diabetes created in research by administering streptozotocin, leading to the destruction of insulin-secreting cells in the pancreas.[3]