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Significance of Streptozotocin

Streptozotocin is a chemical compound utilized in experimental settings to induce diabetes in laboratory animals by damaging pancreatic beta cells. It is frequently administered to rats and can also be used in other animals, such as rabbits, for research purposes. This compound is noted for its selective toxicity to insulin-producing cells in the pancreas, enabling researchers to create diabetic models for studying antidiabetic interventions and the effects of treatments on diabetic complications.

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The concept of Streptozotocin in scientific sources

Science Books

Streptozotocin is a chemical compound employed in research to induce diabetes in rats by selectively damaging insulin-producing beta cells, making it a crucial tool for studying diabetes in animal models.

Significance in Scientific journals, articles, etc.:

From: The Malaysian Journal of Medical Sciences

(1) This substance was used in combination with nicotinamide to induce micronuclei formation in the experimental setup involving rats.[1] (2) This is a diabetogenic factor with cytotoxic effects on pancreatic beta cells, which was used to induce diabetes in the mice, leading to the destruction of beta cells.[2] (3) Streptozotocin, also known as STZ, is used in the animal model of Alzheimer's disease, and its local injection at a sub-diabetogenic dose creates a similar pathology.[3] (4) A chemical used to induce diabetes in experimental animal models by destroying insulin-producing beta cells in the pancreas.[4]

This section includes scientific research in the field of healthcare, often involving traditional medicine systems such as Ayurveda, Unani, Siddha and Holistic health. It includes papers from scientific journals classified as either original, clinical or experimental research, review articles or case reports.