Significance of Pure Red Cell Aplasia
Pure Red Cell Aplasia (PRCA) is a rare condition marked by the failure of erythropoiesis while preserving granulopoiesis and megakaryopoiesis, often linked to thymoma. It results in isolated normochromic, normocytic anemia, reticulocytopenia, and erythroid hypoplasia in the bone marrow. Additionally, PRCA can be induced by Parvo virus B19 infection, leading to normocytic anemia and a normal count of white blood cells and platelets. This highlights the complexity and potential causes of PRCA.
Synonyms: Anemia, Bone marrow disorder
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The concept of Pure Red Cell Aplasia in scientific sources
Pure Red Cell Aplasia (PRCA) is a rare bone marrow failure characterized by normocytic anemia and reticulocytopenia, while preserving other blood components. It can arise from thymoma complications or infections like Parvo virus B19.
From: The Malaysian Journal of Medical Sciences
(1) A condition characterized by failure of erythropoiesis, with preserved granulopoiesis and megakaryopoiesis, which can occur as a complication of thymoma.[1] (2) PRCA represents an isolated process, characterized by normochromic, normocytic anaemia, reticulocytopenia and erythroid hypoplasia in the bone marrow, and may be attributable to infection with Parvo virus B19.[2]