Significance of Preclinical research
Preclinical research is a critical phase conducted before clinical trials, involving laboratory testing and studies on animal models. This research assesses the potential efficacy and safety of treatment interventions and drug formulations. It plays a vital role in evaluating the safety and efficacy of drug candidates prior to human testing. By ensuring that drugs and vaccines are safe for human trials, preclinical research is essential in the drug development process.
Synonyms: Biomedical research, Laboratory research, Experimental research, Translational research, Preclinical studies, Animal studies, Non-clinical testing, In vitro testing.
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Preclinical research in scientific sources
Preclinical research is the essential phase before clinical trials, focusing on laboratory studies with experimental models to evaluate the safety and efficacy of potential treatments, ensuring they are suitable for human testing.
From: World Journal of Pharmaceutical Research
(1) Laboratory studies that assess the therapeutic effects of formulations or drugs before they are tested in humans.[1] (2) Investigative studies conducted in lab settings to assess the potential efficacy and safety of treatment interventions before clinical trials.[2] (3) Research conducted to evaluate drug safety and efficacy using animal models before advancing to human trials.[3] (4) Research conducted to determine the safety and efficacy of drug candidates before they are tested in human subjects.[4] (5) The phase of vaccine development that occurs before human clinical trials, involving tests on laboratory animals.[5]
From: AYU (Journal of Research in Ayurveda)
(1) The phase of research that occurs before clinical trials, involving laboratory studies on experimental models to ensure safety and efficacy.[6]