Significance of Phase separation
Phase separation is the process where different components in a formulation become distinct, which can lead to instability and affect product efficacy. This phenomenon can occur in various contexts, such as emulsions, solid dispersions, and tissue engineering scaffolds. Observations of phase separation, indicated by component separation over time, are critical in stability tests to ensure formulations maintain their uniformity. Overall, understanding phase separation is essential for developing stable and effective products in pharmaceutical and cosmetic formulations.
Synonyms: Phase partitioning, Segregation, Differentiation
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The concept of Phase separation in scientific sources
Phase separation involves the formation of distinct regions in materials, impacting drug dissolution in solid dispersions, altering material properties due to blend ratios, and leading to liquid-to-solid transformations in injected formulations through solvent removal.
From: World Journal of Pharmaceutical Research
(1) A phenomenon where different components of a formulation separate, which can affect the quality of the final lyophilized product.[1] (2) The occurrence in emulsions where the components separate into distinct layers or phases due to improper formulation concentration.[2] (3) A condition noted in stability testing that indicates if the components of a formulation remain mixed or begin to separate over time.[3] (4) The occurrence where components of a mixture become separated into distinct phases, which can affect product stability and efficacy.[4] (5) A phenomenon that can occur during the cooling of drug-matrix mixtures, leading to the formation of distinct phases of substances instead of a uniform mixture.[5]