Significance of Neoplastic transformation
Neoplastic transformation is the process by which normal cells undergo changes that lead to the development of cancerous cells. This transformation can occur through various influences, including mutations from infections and damage from reactive oxygen species. It involves the acquisition of cancer cell characteristics, often related to the activation of specific pathways such as Wnt/TCF. This multi-step process results in the loss of normal cellular controls, ultimately disrupting local tissue architecture and function, and is an important area of research.
Synonyms: Tumorigenesis, Oncogenesis, Cancer development, Malignant transformation, Carcinogenesis
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The concept of Neoplastic transformation in scientific sources
Neoplastic transformation is the process where normal cells change and develop into cancerous cells. This transformation is a critical research area, especially within studies using animal models to understand cancer development.
From: The Malaysian Journal of Medical Sciences
(1) The process by which infected cells mutate and develop into cancerous cells due to various influences.[1] (2) A multi-step process where normal cellular controls of proliferation and interactions are lost, leading to the transformation of normal cells into cancerous tumor cells.[2]