Significance of Negative control
Negative control refers to a group in experimental research that does not receive the treatment under investigation, serving as a benchmark for comparison with treated groups. This control is utilized to ensure that the experimental results are due to the treatment and not external factors. Additionally, negative controls help validate the accuracy of tests by confirming the absence of the target substance, ensuring no false positives. Thus, negative control is critical for robust scientific experimentation and result interpretation.
Synonyms: Placebo, Control group, Baseline, Reference group, Standard control, Comparator, Untreated group
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Negative control in scientific sources
Negative control involves a group not receiving the experimental treatment to establish a baseline and ensure the experiment functions correctly by providing expected negative results for comparison against treated subjects.
From: The Malaysian Journal of Medical Sciences
(1) This is a control used to determine if a serum sample is positive, when the OD value is two-fold higher than the negative control, as stated in the text.[1] (2) This is a probe prepared from pUC18 plasmid DNA, used to ensure the specificity and reliability of the in situ hybridization results.[2] (3) A negative control, like 1× PBS, is a substance that is not expected to produce an effect and is used as a baseline for comparison in the experiments.[3] (4) A group of non-HD individuals whose PBMCs were used as a negative control in the experiment.[4] (5) These are experimental samples that are expected to show a negative result, used to ensure the test method is not giving false positives.[5]