Significance of Minimum inhibitory concentration
Minimum inhibitory concentration (MIC) is defined as the lowest concentration of an antimicrobial agent that effectively prevents visible growth of a microorganism during a specified incubation period. This measurement is crucial for assessing antibiotic resistance patterns and determining the effectiveness of various antimicrobial agents, including plant extracts and antibiotics, against specific bacterial strains. By identifying the MIC values, researchers can evaluate the potency of different compounds in inhibiting microbial growth, which is essential for developing effective treatment strategies.
Synonyms: Mic, Inhibitory concentration, Minimal inhibitory concentration
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The concept of Minimum inhibitory concentration in scientific sources
Minimum inhibitory concentration (MIC) is the smallest concentration of an antimicrobial agent that effectively prevents microbial growth, serving as a critical metric in assessing the potency and efficacy of antimicrobial substances through techniques like serial dilution.
From: The Malaysian Journal of Medical Sciences
(1) This is the MIC of bacteria-resistant organisms that the current dose used in the ICU is not guided by.[1] (2) Leaves from Terminalia catappa extracted with petroleum ether, chloroform or ethyl acetate also inhibit agar growth of foodborne Escherichia coli, yielding these values.[2] (3) The lowest concentration of a substance that is required to prevent the growth of a specific microorganism, used to determine effectiveness.[3] (4) Minimum inhibitory concentrations (MICs) and plant flavonoids as antibacterials are used to combat MDR bacteria, indicating that natural plant products can be a useful source.[4] (5) This represents the lowest amount of a substance that can stop the growth of a specific microorganism, determined through a microdilution assay.[5]