Significance of Growth arrest
Growth arrest is a biological mechanism initiated by the protein p53 that halts cell division in response to DNA damage. This process serves as a protective measure, allowing cells time to repair damaged DNA before continuing to proliferate. By inducing growth arrest, p53 plays a crucial role in maintaining genomic integrity and preventing the potential development of cancers resulting from uncontrolled cell division.
Synonyms: Growth inhibition, Stagnation
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The concept of Growth arrest in scientific sources
Growth arrest is a protective mechanism initiated by the p53 protein that halts cell division when DNA damage is detected, preventing the propagation of damaged cells and maintaining genomic integrity.
From: World Journal of Pharmaceutical Research
(1) A halting of cell proliferation; ALA treatment impacted growth arrest indicating its effects on cancer cell dynamics.[1] (2) A mechanism initiated by p53 to stop cell division in response to DNA damage.[2]