Significance of Compatibility studies
Compatibility studies involve extensive research to assess the interactions between a drug and its excipients, ensuring stability and efficacy in pharmaceutical formulations. These studies aim to determine whether a drug and excipients can coexist without causing adverse reactions, thus maintaining the safety and effectiveness of the final product. Various techniques, such as FTIR and DSC, are employed to evaluate any potential chemical or physical interactions that could impact the drug's stability and overall formulation success.
Synonyms: Consistency evaluation, Compatibility assessment
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The concept of Compatibility studies in scientific sources
Compatibility studies involve investigations and tests to evaluate the interaction between active ingredients and excipients in pharmaceutical formulations, ensuring they do not negatively interact and thus preventing incompatibility issues.
From: World Journal of Pharmaceutical Research
(1) Research conducted to assess the interactions between a drug and its excipients to ensure stability and efficacy.[1] (2) Evaluations carried out to assess the interaction between drugs and excipients using techniques like IR spectroscopy.[2] (3) Testing to assess whether a drug interacts adversely with excipients or other components of its formulation.[3] (4) Investigations conducted to ensure that the active pharmaceutical ingredients interact properly with the excipients in formulations.[4] (5) An examination of how Pioglitazone interacts with various excipients to ensure no adverse reactions occur.[5]
From: AYU (Journal of Research in Ayurveda)
(1) Tests conducted to ensure that the active ingredients and excipients do not adversely interact with each other.[6]