Significance of Cellular senescence
Cellular senescence is the permanent arrest of the cell cycle, where cells stop dividing due to stressors, oxidative damage, or critically short telomeres. This phenomenon is associated with aging and plays a significant role in age-related diseases. As cells lose their ability to function and replicate, they accumulate over time, which can contribute to various health issues. Understanding cellular senescence is essential for research into aging and potential interventions to mitigate its effects.
Synonyms: Cellular aging, Cell senescence, Senescent cells, Replicative senescence, Cell cycle arrest
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The concept of Cellular senescence in scientific sources
Cellular senescence is the process where cells cease to divide and function, playing a crucial role in aging and the development of age-related diseases, as highlighted by regional sources.
From: The Malaysian Journal of Medical Sciences
(1) This is a state of cell cycle arrest, and it is a factor that contributes to stem cell exhaustion during aging.[1] (2) Studies in model organisms including human have continually established new theories, introducing various approaches to study this and ageing process.[2] (3) A state in which cells cease to divide and function properly, often as a response to stress or damage, which can be accelerated in diabetic tissues.[3] (4) Cellular senescence refers to the state of permanent cell cycle arrest that occurs in response to various stressors, leading to changes in cell function and morphology.[4]