Significance of Bone remodeling
Bone remodeling is a biological process involving the continuous renewal of bone tissue through the resorption of old bone and the formation of new bone. This process is vital for maintaining bone health, as an imbalance—where resorption exceeds formation—can lead to conditions like osteoporosis and osteopenia. Factors such as estrogen deficiency, oxidative stress, mechanical forces, and biochemical signals can influence bone remodeling, contributing to the ongoing physiological changes and health of the bone structure.
Synonyms: Bone resorption, Bone turnover, Bone metabolism, Bone regeneration, Bone formation
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The concept of Bone remodeling in scientific sources
Bone remodeling is a biological process involving bone formation and resorption, which can become disrupted due to estrogen deficiency after menopause, potentially leading to osteoporosis and highlighting its imbalance in such diseases.
From: The Malaysian Journal of Medical Sciences
(1) Bone remodeling is a continuous process where old bone tissue is removed and replaced with new bone, involving the coordinated activity of bone-forming and bone-resorbing cells.[1] (2) A process that involves the breakdown and rebuilding of bone tissue, and is affected by factors like estrogen deficiency and oxidative stress, impacting bone health.[2] (3) The process by which bone is continuously renewed by a balance of bone resorption and bone formation.[3] (4) The biological process involving the balance of bone resorption and formation, primarily mediated by osteoblasts and osteoclasts.[4]