Review on Cissus quadrangularis: ethnobotany, phytochemistry, pharmacology.
Journal name: World Journal of Pharmaceutical Research
Original article title: Review on ethnobotany, phytochemistry and pharmacology of cissus quadrangularis, linn
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Kandasamy Palanisamy Jaiganesh, B. Prathap, Dhivyavarshini Baskaran, Mahalingam Mageswaran and Givondasamy Pravin
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Review on ethnobotany, phytochemistry and pharmacology of cissus quadrangularis, linn
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr202114-22280
Copyright (license): WJPR: All rights reserved
Download the PDF file of the original publication
Summary of article contents:
Introduction
Cissus quadrangularis, commonly known as Hadjod, is a succulent herb belonging to the family Vitaceae, recognized for its various medicinal properties across different traditional systems of medicine, including Ayurveda and Unani. This perennial plant reaches a height of about 1.5 meters and boasts distinctive square stalked vines. In traditional medicine, Cissus quadrangularis is prized for its roles in digestive aid, bone strengthening, treating respiratory issues, and as an aphrodisiac. Its therapeutic applications extend to the treatment of conditions like gastritis, asthma, and bone fractures, making it an important herbal remedy with historical significance in various cultures.
Bone Healing Properties
A key highlight of Cissus quadrangularis is its remarkable bone-healing properties, often described in Ayurveda as �Asthi Samharaha,� translating to “Pacification of bones.� Traditionally used for the treatment of fractures, both the powdered root and the whole plant have garnered attention for promoting faster healing of bones. Clinical studies suggest that the plant stimulates osteoblast activity, facilitating bone regeneration and mineralization. These effects are attributed to the rich nutrient composition of the plant, including essential minerals like calcium and phosphorus. Several studies have indicated the plant’s efficacy in shortening fracture healing time and enhancing the structural integrity of bones.
Antioxidant and Anti-inflammatory Actions
Cissus quadrangularis exhibits potent antioxidant properties which contribute to its therapeutic profile. The methanol extract of the plant has demonstrated significant antioxidant activity through various in vitro and in vivo models, mainly attributed to its high content of β-carotene and other phenolic compounds. This antioxidant capacity aids in reducing oxidative stress, which is crucial for managing inflammation and protecting against various chronic diseases. Additionally, the anti-inflammatory action of Cissus quadrangularis is beneficial in treating conditions associated with pain and swelling, further expanding its utility in alternative medicine.
Gastroprotective Effects
The gastroprotective qualities of Cissus quadrangularis are increasingly recognized, especially in the context of traditional treatments for gastric disorders. The plant has shown efficacy against gastric toxicity induced by non-steroidal anti-inflammatory drugs (NSAIDs) through mechanisms that enhance glycoprotein levels in the gastric mucosa and inhibit oxidative damage. Studies reflect its potential role in ameliorating gastric ulcers through its rich profile of carotenoids and triterpenoids, highlighting its application as a natural supplement for gastrointestinal health.
Conclusion
Cissus quadrangularis stands out as a significant herbal medicine with a diverse range of therapeutic applications, particularly in bone health, antioxidant activity, and gastrointestinal protection. Its integration into modern therapeutic practices, especially concerning weight loss and management of osteopathic disorders, underscores its relevance in contemporary health solutions. Given its minimal toxicity profile and multifaceted health benefits, Cissus quadrangularis deserves further scientific exploration and clinical validation, promising to bridge traditional knowledge with modern pharmacological research.
FAQ section (important questions/answers):
What is Cissus quadrangularis and its common uses?
Cissus quadrangularis, known as Hadjod or Adamant creeper, is used in traditional medicine for various ailments, including bone healing, digestion, and as an aphrodisiac. It is commonly employed in Ayurveda and Unani systems for its therapeutic properties.
What are the prominent phytochemical compounds found in Cissus quadrangularis?
Cissus quadrangularis contains carotenoids, triterpenoids, ascorbic acid, flavonoids, and calcium. The presence of compounds like β-sitosterol and resveratrol contributes to its antioxidant, anti-inflammatory, and bone healing activities.
How does Cissus quadrangularis contribute to bone health?
Cissus quadrangularis promotes bone healing by enhancing mineral uptake, stimulating osteoblasts, and accelerating connective tissue regeneration. Its antiosteoporotic properties make it beneficial for patients with osteoporosis.
What traditional ailments can Cissus quadrangularis treat?
Traditionally, Cissus quadrangularis is used to treat gastritis, fractures, asthma, constipation, irregular menstruation, and skin infections. Its versatility makes it a staple in Ayurvedic remedies.
Are there any reported toxicities associated with Cissus quadrangularis?
Toxicity studies show that Cissus quadrangularis exhibits no significant side effects at therapeutic doses. It did not produce harmful changes in hematological parameters or cause lesions in internal organs during testing.
What are the applications of Cissus quadrangularis in modern medicine?
Cissus quadrangularis shows potential in weight-loss formulations, antimicrobial treatments, and as a supplement for various ailments due to its rich phytochemical profile and minimal toxicity, warranting further pharmacological investigations.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Review on Cissus quadrangularis: ethnobotany, phytochemistry, pharmacology.�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
Activity refers to the various biological functions and actions performed by compounds within Cissus quadrangularis. These include antioxidant, anti-inflammatory, analgesic, and antibacterial functions among others, which are critical for understanding the plant's therapeutic potential in treating various ailments and for its use in traditional medicine.
2) Study (Studying):
Study refers to the systematic investigation of Cissus quadrangularis to understand its pharmacological properties, chemical composition, and potential health benefits. Research efforts are essential for validating the claims made in traditional medicine and for paving the way for future scientific exploration and possible new therapeutics.
3) Rope:
In the context of cultivating Cissus quadrangularis, the 'rope' serves as a support structure for the plant's growth. As this plant is a climbing vine, utilizing ropes or wires allows the stems to climb, thereby optimizing space and ensuring optimal exposure to sunlight for photosynthesis.
4) Powder:
Powder refers to the processed form of Cissus quadrangularis, typically derived from dried stems or roots. This powdered form is often utilized in traditional medicine practices for its health benefits, as it is easier to measure and incorporate into various formulations for therapeutic use.
5) Toxicity:
Toxicity studies evaluate the safety profile of Cissus quadrangularis by determining the potential harmful effects of its consumption. Understanding toxicity is vital for establishing safe dosage levels and confirming that the plant can be used in treatments without causing adverse effects.
6) Water:
Water plays a crucial role in the cultivation of Cissus quadrangularis. Appropriate irrigation practices are necessary to ensure optimal growth and development. Additionally, water serves as a vital solvent for the extraction of bioactive compounds from the plant for research and therapeutic applications.
7) Pharmacological:
Pharmacological relates to the study of the effects of Cissus quadrangularis on biological systems. It encompasses the investigation of the plant's therapeutic benefits, mechanisms of action, and interactions with various bodily systems, thereby contributing to a greater understanding of its medicinal value.
8) Antibiotic (Antibacterial):
Antibacterial activity of Cissus quadrangularis is particularly significant in traditional medicine, where it is used for treating infections. Understanding its antibacterial properties allows researchers to explore its potential as a natural remedy for various bacterial infections, influencing future drug development.
9) Mineral:
Minerals signify the essential nutrients found in Cissus quadrangularis, crucial for several biological functions, particularly bone health. Understanding its mineral content aids in validating traditional claims and supports its use in treating mineral deficiency-related health issues.
10) India:
India is the native region for Cissus quadrangularis, where it has been used in traditional medicine systems like Ayurveda. Its usage in India reflects the rich biodiversity of the area and highlights the importance of indigenous knowledge in herbal medicine.
11) Blood:
Blood is significant in the context of Cissus quadrangularis due to studies that investigate the plant's effects on blood parameters, including blood glucose levels and its potential to aid in managing diseases like diabetes. Understanding this relation can enhance its therapeutic profile.
12) Flavonoid:
Flavonoids are a class of phytochemicals present in Cissus quadrangularis, known for their antioxidant properties. These compounds contribute to the plant's health benefits and play a role in preventing various diseases, supporting its use in traditional and complementary medicine.
13) Surface:
Surface refers to aspects related to the botanical characteristics of Cissus quadrangularis. Understanding surface texture, leaf characteristics, and stem structure helps in identification and classification, which is essential for botanical studies and medicinal applications.
14) Family:
Family refers to the taxonomic classification of Cissus quadrangularis within the Vitaceae family. Understanding its family grouping helps researchers understand its ecological traits, relationships with other plants, and potential shared properties within the family that may influence medicinal uses.
15) Tamil:
Tamil pertains to the language and culture of the Tamil people in India, where Cissus quadrangularis is widely used. The linguistic context adds depth to understanding local traditional medicinal practices and the cultural significance of the plant in regional health systems.
16) Cow dung:
Cow dung is an important organic material used in the cultivation of Cissus quadrangularis as fertilizer. Its nutrient content supports growth, enriching the soil with essential minerals and improving soil quality, which is vital for the plant's health and yield.
17) Perambalur:
Perambalur is a district in Tamil Nadu, India, where Cissus quadrangularis is cultivated and studied. The area's agricultural practices and biodiversity contribute to the plant's availability and underscore its significance in local traditional medicine and research.
18) Tamilnadu (Tamil-nadu):
Tamil Nadu is a southern state in India known for rich biodiversity and traditional medicine practices. Cissus quadrangularis is part of this cultural heritage, contributing to local health practices and serving as a subject for scientific exploration within this context.
19) Medicine:
Medicine encompasses the comprehensive field of health care practices that involve the use of plants like Cissus quadrangularis for healing. Traditional and modern medicinal systems benefit from the investigation of plant compounds to develop therapeutic applications for various ailments.
20) Disease:
Diseases encompass the various health conditions that Cissus quadrangularis potentially addresses. Traditional uses and pharmacological research spotlight the importance of the plant in treating a range of conditions, expanding its application in herbal medicine.
21) Ulcer:
Ulcer refers to a common digestive ailment where Cissus quadrangularis has demonstrated protective properties. Its role in protecting against gastric mucosal damage showcases its therapeutic potential and aligns with traditional claims regarding its use in treating gastrointestinal disorders.
22) Nadu:
Nadu is part of the name Tamil Nadu, emphasizing the regional specificity. The inclusion of this word highlights the geographical and cultural context of Cissus quadrangularis, underscoring its local significance in both agriculture and traditional medicine.
23) Drug:
Drugs refer to preparations derived from Cissus quadrangularis that are explored for their medicinal applications. Understanding the transformation of plant compounds into drug formulations underlines the bridge between herbal medicine and contemporary pharmacology.
24) Phytochemical:
Phytochemical refers to the chemical compounds derived from Cissus quadrangularis that exhibit biological effects. Studying these compounds is crucial for understanding their health benefits and therapeutic mechanisms, leading to possible applications in drug development and health promotion.
25) Pharmacology:
Pharmacology is the scientific study of drugs and their effects on living organisms. Cissus quadrangularis, through its various biological activities, plays a significant role in pharmacology by demonstrating how plant-based substances can influence health and wellness.
26) Knowledge:
Knowledge emphasizes the importance of understanding the uses, benefits, and potential risks of Cissus quadrangularis. Expanding knowledge regarding medicinal plants enhances their application in modern medicine and inspires further research in ethno-pharmacology.
27) Ayurveda (Ayus-veda):
Ayurveda is a traditional system of medicine originating in India that extensively incorporates Cissus quadrangularis for its reputed health benefits. The plant's integration into Ayurveda reflects its historical significance and ongoing relevance in holistic wellness practices.
28) Species:
Species refers to the biological classification of Cissus quadrangularis within the plant kingdom. Its identification as a distinct species is vital for research, cultivation, conservation, and understanding its unique properties and applications in medicine.
29) Animal:
In this context, animal refers to the biological testing subjects used to evaluate the pharmacological effects of Cissus quadrangularis. Testing on animals is a critical step in assessing safety and effectiveness before potential human application.
30) Aureus:
Aureus, as in Staphylococcus aureus, highlights one of the bacterial strains against which Cissus quadrangularis has shown antibacterial activity. Understanding its effects on specific pathogens is essential for exploring its therapeutic potential in treating infections.
31) Bitter:
Bitter describes one of the taste profiles associated with Cissus quadrangularis. The bitterness of specific phytochemicals may correlate with therapeutic properties, contributing to traditional beliefs regarding health benefits and the plant's overall medicinal profile.
32) Asthi (Ashthi):
Asthi refers to the Sanskrit term meaning 'bone,' highlighting the cultural association of Cissus quadrangularis with bone healing. This connection underscores the traditional use of the plant for enhancing bone strength and recovery from fractures.
33) Table:
Table refers to the organized presentation of data or information, as seen in the described studies on Cissus quadrangularis. Tables are useful for summarizing key findings, comparing results, and presenting statistics in an accessible format.
34) Field:
Field refers to the area of agriculture where Cissus quadrangularis is cultivated. Understanding the agricultural context assists in recognizing the plant's growth requirements, cultivation techniques, and integration into local farming practices.
35) Ripe:
Ripe relates to the maturity stage of Cissus quadrangularis fruits or parts, indicating the optimal time for harvesting. Recognizing ripeness is crucial for ensuring the maximum chemical composition and potency of the plant's therapeutic properties.
36) Rich (Rch):
Rich describes the quality of Cissus quadrangularis in terms of its concentration of beneficial phytochemicals, vitamins, and minerals. A 'rich' profile enhances its appeal for traditional and modern medicine, emphasizing its health-promoting properties.
37) Post:
Post indicates the period after an event, such as harvesting or treatment. In research, 'post' often refers to observations made after administering Cissus quadrangularis, examining long-term effects and benefits in various health contexts.
38) Southern India:
Southern India is a regional context where Cissus quadrangularis is commonly found and used in traditional practices. The cultural practices in this region contribute to the generations of knowledge pertaining to the healing qualities of the plant.
39) Inflammation:
Inflammation refers to a biological response that Cissus quadrangularis is known to help alleviate. Understanding its anti-inflammatory properties solidifies its role in treating various health conditions, especially those involving tissue damage or irritation.
40) Observation:
Observation refers to the process of monitoring and recording data during studies involving Cissus quadrangularis. Careful observations help inform researchers about the plant's effects and contribute to the body of knowledge regarding its medicinal qualities.
41) Performance:
Performance in this context relates to the effectiveness of Cissus quadrangularis in therapeutic applications and clinical settings. Evaluating its performance aids in gauging potential benefits and impacts on conditions such as bone fractures and infections.
42) Science (Scientific):
Science refers to the systematic study of Cissus quadrangularis, exploring its pharmacological properties, therapeutic potential, and bioactive compounds. Scientific research contributes to validating traditional claims and advancing the integration of such plants into modern healthcare.
43) Harvesting (Harvest):
Harvest emphasizes the timing and techniques used to collect Cissus quadrangularis at its peak potency. Effective harvesting strategies ensure that the plant's medicinal properties are retained, enabling optimal use in various therapeutic applications.
44) Blindness:
Blindness is a health condition that may be addressed by using Cissus quadrangularis. Traditional practices often cite the plant's potential to aid various eye-related ailments, further emphasizing the need for scientific exploration into its effectiveness.
45) Composite:
Composite may refer to the formulation of products that combine Cissus quadrangularis with other natural ingredients. Such composite formulations are often used in traditional medicine to enhance therapeutic effects and create synergistic benefits.
46) Gujarati:
Gujarati refers to the language and culture in the western Indian state of Gujarat. Recognizing the cultural significance of Cissus quadrangularis in regional contexts reflects the broad use of the plant across various Indian traditional medicinal practices.
47) Bleeding:
Bleeding can indicate various health issues that Cissus quadrangularis might be utilized to address, particularly in the context of wound healing or gastrointestinal concerns. Understanding its role in managing bleeding further underscores the plant's medicinal potential.
48) Epilepsy:
Epilepsy is a neurological condition that Cissus quadrangularis has been noted in traditional texts to assist with. Investigating its effects on epilepsy symptoms aligns with broader research goals of identifying natural remedies for managing chronic conditions.
49) Sanskrit:
Sanskrit is an ancient language of India, where traditional medicinal texts document the uses of Cissus quadrangularis. Understanding Sanskrit terms related to the plant enriches the knowledge surrounding its historical and cultural significance in Ayurvedic medicine.
50) Shri-lanka (Srilanka, Sri-lanka, Shrilanka):
Srilanka, as a geographical context, highlights the distribution of Cissus quadrangularis beyond India. The use of the plant in Sri Lankan traditional practices indicates its value in herbal medicine within South Asian cultures.
51) Marathi:
Marathi is the regional language spoken in Maharashtra, India, where Cissus quadrangularis may be known by different names. Understanding local terminology aids in recognizing the widespread influence of the plant in various cultural medicinal applications.
52) Bengali:
Bengali refers to the language and culture of Bengal, where Cissus quadrangularis is also acknowledged for its medicinal properties. The reference to Bengali underscores the plant's cross-regional presence and importance in traditional health practices.
53) Chennai:
Chennai, a major city in Southern India, plays a significant role in the cultivation and use of Cissus quadrangularis. It symbolizes urban centers where traditional medicine meets modern healthcare, aiding in expanded research and accessibility of the plant.
54) Habitat:
Habitat refers to the natural environment where Cissus quadrangularis thrives. Understanding its habitat preferences aids in conservation efforts, sustainable cultivation, and ensures that research into its medicinal properties is grounded in environmental realities.
55) Cutting:
Cutting refers to a method for propagating Cissus quadrangularis, where stem sections are used for planting. This technique is key for sustaining its cultivation, enabling the plant's therapeutic potential to be harnessed consistently across regions.
56) Nostril:
Nostril refers to the method of administering Cissus quadrangularis juice in traditional practices for treating epistaxis. Understanding its application through nostrils emphasizes the plant's diverse usage in alternative medicine for specific health conditions.
57) Siddha:
Siddha is a traditional medicine system originating in South India that incorporates the use of Cissus quadrangularis. Understanding Siddha practices enriches the narrative of the plant's therapeutic roles in diverse cultural medical frameworks.
58) Autumn:
Autumn may signify a seasonal context for harvesting or growth patterns of Cissus quadrangularis. Understanding seasonal influences aids in agricultural planning and the management of plants that have specific growth cycles.
59) Cancer:
Cancer refers to a serious health condition that researchers are examining Cissus quadrangularis for potential therapeutic effects against. The exploration of its properties may provide new avenues in cancer treatment and health maintenance.
60) Repair:
Repair highlights the capability of Cissus quadrangularis to facilitate healing, particularly in bone and tissue repair. Understanding the plant's restorative functions emphasizes its value in both traditional and modern therapeutic applications.
61) Nature:
Nature signifies the ecological context of Cissus quadrangularis as a natural product used in traditional medicine. Embracing a 'natural' paradigm aligns with a growing trend towards using plant-based remedies in health practices.
62) Filling (Filled):
Filled may describe the composition of Cissus quadrangularis in terms of its nutrient or chemical content. Understanding its filled properties aids in assessing its completeness as a health-promoting ingredient.
63) Botany:
Botany emphasizes the scientific study of plants, including Cissus quadrangularis. Knowledge in botany enables researchers to classify, understand, and utilize plants effectively in medicinal and therapeutic contexts.
64) Manure:
Manure, such as cow dung, is essential for enriching the soil in which Cissus quadrangularis is grown. Its application supports sustainable agricultural practices while enhancing the growth and yield of medicinal plants.
65) Valli:
Valli refers to a traditional name for Cissus quadrangularis in certain regional languages, illustrating the cultural perspectives surrounding the plant. Recognizing local nomenclature enriches understanding of its historical usage in diverse communities.
66) Hindi (Himdi):
Hindi, as a language, brings attention to the cultural and linguistic aspects of Cissus quadrangularis within Northern India, highlighting its presence and significance in regions using this language in herbal medicine.
67) Death:
Death may refer to conditions or ailments addressed by Cissus quadrangularis, particularly in terms of health preservation. Understanding the plant's potential impact on mortality can galvanize interest in its medicinal benefits.
68) Oriya:
Oriya refers to the language spoken in the state of Odisha, India. This highlights the widespread cultural significance of Cissus quadrangularis, emphasizing its roots in multiple medicinal practices across different regions.
69) Burning (Burn, Burned, Burnt):
Burn generally signifies heat-related injuries, which Cissus quadrangularis may be utilized to treat, emphasizing its role in traditional medicine practices for healing skin and tissue damage.
70) Genu:
Genu, while potentially a typographical error, may refer to the botanical aspects within the context of Cissus quadrangularis, underscoring the significance of the plant's classification in the broader study of botany.
71) Viti:
Viti is a term likely related to the family Vitaceae, which includes Cissus quadrangularis. Understanding its familial context is essential in exploring shared characteristics with other plants and their uses in traditional and herbal medicine.
72) Shri (Sri, Sr):
Shri is an honorific used in Indian culture, often before the names of respected individuals. In the context of the paper, it suggests respect and acknowledges the contributions of figureheads involved in the research or publication.
73) Sara (Shara):
Sara refers to Ayurvedic terminology relating to the qualities of Cissus quadrangularis, emphasizing its use as a digestive aid. Such traditional attributes contribute to the plant's holistic applications in health and wellness.
74) Heap:
Heap may describe the collected organic material used as fertilizer for Cissus quadrangularis. Understanding its agricultural practices reflects the community strategies applied in maintaining the plant's growth and health.
75) Wall:
Wall may refer to the structural aspects of the plant as it grows or the physical support mechanisms employed in its cultivation. Recognizing structural adaptations is important for effective agricultural planning.
[Note: The above list is limited to 75. Total glossary definitions available: 79]
Other Science Concepts:
Discover the significance of concepts within the article: �Review on Cissus quadrangularis: ethnobotany, phytochemistry, pharmacology.�. Further sources in the context of Science might help you critically compare this page with similair documents:
Cissus quadrangularis, Traditional Indian medicine, Antioxidant properties, Anti-microbial activity, Pharmacological action, Gastroprotective Activity, Central nervous system activity, Weight loss formulation.