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New insights on natural molecules' antiviral effects against COVID-19

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Journal name: World Journal of Pharmaceutical Research
Original article title: Novel perception on the anti - viral effect of bioactive natural molecules against covid -19
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Author:

M. A. Nandedkar, S. V. Mahajan, K. M. Pardeshi, R. J. Oswal and M. S. Shah


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Novel perception on the anti - viral effect of bioactive natural molecules against covid -19

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20207-17843

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has emerged as a significant global health crisis since its identification in Wuhan, China, in late 2019. As of May 28, 2020, millions of confirmed cases and substantial fatalities underscored the urgent need for effective treatment and preventive measures. Traditional and complementary medicine, specifically herbal remedies, are gaining attention for their potential antiviral properties against COVID-19. This review explores the antiviral effects of various bioactive natural molecules derived from traditional Indian herbs, highlighting their role in developing alternative therapies against COVID-19.

The Promise of Herbal Medicine

Herbal medicine has been utilized for centuries to treat a range of ailments, and its resurgence in interest during the COVID-19 pandemic is largely due to safety concerns surrounding synthetic pharmaceuticals. The review discusses several natural products, including Turmeric, Ashwagandha, Clitoria ternatea, and Ginger, demonstrating their inhibition potential against SARS-CoV-2, often exceeding that of well-known anti-malarial drugs like Chloroquine and Hydroxychloroquine. The inherent toxicity and side effects associated with these synthetic drugs have prompted many individuals to turn to herbal medicine for their primary healthcare needs, emphasizing the importance of exploring natural alternatives for managing viral infections.

Mechanisms of Antiviral Action

The article elucidates the mechanisms through which various natural compounds exert their antiviral effects. These phytoconstituents contain active components such as flavones, alkaloids, and polyphenols, which play critical roles in targeting the viral life cycle, including viral entry, replication, and assembly. By inhibiting key steps in viral propagation, these herbal remedies may enhance immune responses and mitigate the severity of infections. The review emphasizes the necessity for further research to understand the specific pathways through which these natural products can modulate viral activities and boost host immunity against COVID-19.

Herbal Formulations for COVID-19 Management

The review provides insights into specific herbal formulations that could be used for various stages of COVID-19 infection. It categorizes potential prophylactic and therapeutic approaches based on symptom severity, ranging from asymptomatic individuals to those with moderate to severe symptoms. Formulations incorporating multiple herbs, such as Sanjeevani Vati and combinations of medicinal plants like Giloy, Turmeric, and Ashwagandha, are suggested for their broad-spectrum antiviral properties. This integrative approach illustrates how traditional Ayurvedic practices may complement modern medical treatments, providing a holistic framework for managing the disease.

Conclusion

In conclusion, the COVID-19 pandemic has highlighted the importance of exploring alternative therapies beyond conventional pharmaceuticals. The rich tradition of Indian herbal medicine offers promising avenues for the development of new antiviral agents against SARS-CoV-2. Future research should focus on isolating and characterizing the active components within these plants, as well as conducting clinical trials to evaluate their efficacy in treating COVID-19. Collaborative efforts that integrate traditional knowledge with modern scientific research may lead to innovative solutions for combating not only COVID-19 but also other viral diseases, thereby enhancing global health outcomes.

FAQ section (important questions/answers):

What are bioactive natural molecules' role against COVID-19?

Bioactive natural molecules from herbal plants can enhance immunity and offer antiviral effects against COVID-19, providing an alternative to conventional drugs that may have serious side effects.

What symptoms are commonly associated with COVID-19?

Common symptoms of COVID-19 include fever, dry cough, and tiredness. Less common symptoms can include aches, sore throat, diarrhea, headache, and a loss of taste or smell.

How does COVID-19 primarily spread among people?

COVID-19 primarily spreads through respiratory droplets released when an infected person coughs, sneezes, or talks, as well as through contact with contaminated surfaces.

What treatments are being explored for COVID-19?

Research is ongoing for various treatments, including antiviral and antibacterial drugs, herbal remedies, and COVID-19 vaccines, all aiming to reduce symptoms and manage severe cases.

What is the significance of traditional herbal medicine in treating COVID-19?

Traditional herbal medicine is significant as it provides low-cost alternatives for preventing and managing viral infections, often without severe side effects associated with synthetic medications.

How does herbal medicine help in managing respiratory infections?

Herbal medicine helps manage respiratory infections by boosting immunity, reducing inflammation, and providing antiviral properties through various phytoconstituents found in medicinal plants.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “New insights on natural molecules' antiviral effects against COVID-19�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Viru:
'Viru' is a fundamental term in virology, referring to any virus. It signifies the essence of the infectious agents that can cause diseases, including viruses like SARS-CoV-2. The study of viruses like Viru leads to understanding their transmission, replication, and impacts on host organisms, thereby informing treatment and prevention strategies.

2) Medicine:
'Medicines' encompass a variety of therapeutics, including pharmaceutical drugs and herbal remedies. The development and use of medicines are critical in addressing health issues, particularly in combating and managing viral diseases effectively, highlighting the importance of both modern pharmaceuticals and traditional herbal practices.

3) Disease:
The term 'diseases' encompasses a range of pathological conditions affecting organisms. Understanding diseases is fundamental to medical research, public health, and the development of treatment strategies. Viral diseases like COVID-19 highlight the need for continuous research on prevention, treatment, and the role of herbal medicine in managing health.

4) Drug:
'Drugs' refers to various substances used for medical treatment or relief of symptoms. They include both synthetic pharmaceuticals and natural products derived from plants. The exploration of herbal drugs represents a significant aspect of pharmacology, especially in contexts where synthetic drugs may have high toxicity or side effects.

5) Family:
In biological taxonomy, 'family' is a rank used to classify a group of related organisms sharing common characteristics and evolutionary traits. Understanding the family of various medicinal plants aids in recognizing their properties and potential uses, especially in traditional medicine, thus enhancing herbal resource utilization in treating diseases.

6) Species:
'Species' is a basic unit of classification that defines a group of organisms capable of interbreeding and producing fertile offspring. Identifying the species of medicinal plants, like those used in Ayurvedic medicine, is crucial for pharmacological research and understanding their efficacy against various pathogens and diseases.

7) Transmission:
'Transmission' refers to the spread of a pathogen from one individual to another. Understanding the mechanisms of transmission, particularly for contagious diseases like COVID-19, is vital for implementing effective public health measures aimed at reducing infection rates and protecting at-risk populations.

8) Indian:
The term 'Indian' refers to things related to India, a country known for its rich biodiversity and traditional medicine systems. Indian herbal remedies have been utilized for centuries to combat ailments, and their relevance in treating contemporary health issues, including viral infections, emphasizes the integration of traditional knowledge with modern science.

9) Activity:
'Activity' in this context refers to the biological effects of compounds, particularly their efficacy in combating diseases or infections. The activity of phytochemicals from medicinal plants plays an essential role in drug discovery and in developing alternatives to synthetic drugs used in treating viral illnesses like COVID-19.

10) Rasayana (Rasa-ayana):
'Rasayana' is an Ayurvedic term referring to rejuvenating therapies aimed at promoting health and longevity. It emphasizes holistic well-being and immune enhancement, making it crucial in the context of preventive health strategies against infectious diseases like COVID-19, showcasing traditional medicine's role in modern health care.

11) Study (Studying):
'Study' refers to the systematic investigation of a particular subject to discover facts or principles. Scientific studies are essential in understanding the efficacy of medicinal plants, their active compounds, and their potential role in treating diseases, particularly during health crises like the COVID-19 pandemic.

12) India:
India is known for its rich tradition of herbal medicine, contributing significantly to global knowledge on natural therapeutics. The country’s diverse flora and traditional practices provide essential resources for developing effective treatments against various diseases, particularly in the context of growing health challenges like COVID-19.

13) Rasa (Rasha):
'Rasa' in Ayurveda refers to the essence or flavor of a substance. It encompasses the properties and benefits of medicinal herbs. Understanding the 'rasa' of various plants is crucial for utilizing their health benefits effectively, particularly for enhancing immune responses in the face of viral infections.

14) Vati:
'Vati' is a traditional Ayurvedic form of medication, often presented as a tablet or pill composed of herbal extracts. These preparations provide concentrated therapeutic effects, making them significant for treating specific ailments, including those caused by viral infections, and showcase the traditional methods of health management using natural products.

15) Pharmacological:
'Pharmacological' pertains to the study of drugs and their effects on biological systems. This discipline is vital for evaluating the efficacy, safety, and modes of action of various medicinal compounds, including those derived from plants, in treating diseases like COVID-19, thus enhancing the evidence-based use of herbal medicines.

16) Surface:
In virology, 'surface' describes the outer coatings of viruses, which play a critical role in the virus's ability to bind to host cells and initiate infection. Understanding the surface proteins of SARS-CoV-2 aids in targeting therapeutic approaches that could disrupt these interactions, potentially leading to effective treatment strategies.

17) Cina:
'China' is significant in the context of COVID-19 as the initial epicenter of the outbreak. Its public health response, research efforts, and traditional Chinese medicine practices for treating viral infections have influenced global approaches to managing the pandemic, underlining the interconnectedness of global health challenges and solutions.

18) Indigofera tinctoria:
'Indigofera tinctoria', commonly known as indigo, is a plant notable for its medicinal properties. Research indicates its potential in treating various diseases, including viral infections. The bioactive compounds derived from this plant highlight the importance of exploring traditional medicinal sources for contemporary health challenges, reinforcing the value of biodiversity in disease treatment.

19) Turmeric:
Turmeric, particularly its active compound curcumin, is renowned for its anti-inflammatory and antiviral properties. Widely used in traditional medicine, its potential against viral infections like COVID-19 showcases the importance of natural remedies in a comprehensive health strategy, especially when considering side effects associated with synthetic drugs.

20) Epidemic:
'Epidemic' refers to a sudden increase in disease cases within a population beyond what is normally expected. The COVID-19 epidemic has highlighted the need for effective treatments and preventive measures, encouraging research into traditional medicines that can support immune health and mitigate disease impact on public health.

21) Fever:
Fever is a common symptom of many infectious diseases, including COVID-19. Its presence indicates the body's immune response mechanisms working to combat infection. Understanding fever's role aids in the development of treatments that can support patient recovery and enhance immune function during viral infections.

22) Beta:
'Beta' often refers to beta versions of drugs or compounds in drug discovery, which are under evaluation for efficacy and safety. In this context, understanding beta compounds derived from plants may lead to developing effective therapies for diseases like COVID-19, emphasizing the importance of ongoing research and testing in pharmacology.

23) Phytochemical:
'Phytochemical' denotes chemical compounds produced by plants, many of which exhibit medicinal properties. Identifying and understanding phytochemicals is crucial for developing natural remedies, as they may target viral pathogens effectively, offering alternative treatments to traditional pharmaceuticals with fewer side effects.

24) Flavonoid:
'Flavonoids' are a group of plant metabolites known for their antioxidant and anti-inflammatory properties. They play a significant role in herbal medicine and may exert antiviral effects, making them key components in the study and application of traditional remedies against diseases like COVID-19.

25) Ayurveda (Ayus-veda):
'Ayurveda' is an ancient Indian system of medicine focused on holistic healing. It emphasizes the use of natural remedies and lifestyle changes to promote health and prevent disease. The relevance of Ayurveda in contemporary health care lies in its integration of traditional practices with modern therapeutic approaches, especially in addressing viral infections.

26) Cannabis:
'Cannabis' refers to a plant known for its medicinal properties, including ant-inflammatory and analgesic effects. Research into cannabis-derived compounds contributes to understanding alternative therapeutic options for managing pain and inflammation associated with various diseases, including underlying conditions exacerbated by viral infections like COVID-19.

27) Rich (Rch):
The term 'rich' describes the abundance and diversity of medicinal plants available in particular regions, such as India. This richness provides numerous pharmacological compounds that can be researched for their efficacy against diseases like COVID-19, reinforcing the importance of biodiversity for health innovations and traditional medicine applications.

28) Tinospora cordifolia:
'Tinospora cordifolia', known as Giloy in Ayurveda, is revered for its immune-boosting and antiviral properties. The study of this plant demonstrates the significance of integrating traditional herbal remedies into modern medical practices, especially concerning the search for effective treatments for viral infections like COVID-19.

29) Zingiber officinale:
'Zingiber officinale', commonly known as ginger, is valued for its medicinal properties, particularly its anti-inflammatory and antioxidant effects. Research into ginger's constituents highlights its potential utility in managing symptoms related to viral infections, enhancing its importance in both traditional and complementary medicine practices.

30) Glycyrrhiza glabra:
'Glycyrrhiza glabra', or licorice, is recognized in traditional medicine for its anti-inflammatory and antiviral properties. Understanding its pharmacological effects can aid in the development of therapies for respiratory diseases, including COVID-19, showcasing the relevance of herbal research in contemporary health challenges.

31) Ocimum sanctum:
'Ocimum sanctum', or holy basil/tulsi, is a revered herb in Ayurveda known for its adaptogenic and immunomodulatory effects. It’s potential role in enhancing immunity during viral pandemics underscores the importance of integrating herbal medicine into personal and public health strategies to combat infections.

32) Curcuma longa:
'Curcuma longa', commonly known as turmeric, is a widely used medicinal plant with potent anti-inflammatory, antioxidant, and antiviral properties. Its active compound, curcumin, has been the focus of research aimed at leveraging traditional remedies for contemporary health issues, including those caused by viral infections like COVID-19.

33) Punica granatum:
'Punica granatum', or pomegranate, is noted for its antioxidant and anti-inflammatory properties. Its relevance in traditional medicinal practices adds to the body of research aimed at identifying natural products that may assist in managing viral infections, emphasizing the importance of dietary plants in promoting health and immunity.

34) Allium sativum:
'Allium sativum', known as garlic, is celebrated for its numerous health benefits, including its antiviral and antibacterial properties. The interest in garlic for potential roles in supporting viral infection management underscores the significance of combining traditional knowledge with modern research in pharmacological studies.

35) Inflammation:
Inflammation is a biological response by the body's immune system that can indicate infection or injury. Understanding inflammation’s role in diseases like COVID-19 is crucial for developing therapeutic approaches that can modulate the immune response, using both modern medicine and traditional remedies to support recovery and healing.

36) Maharashtra (Maharastra, Maha-rashtra):
Maharashtra, a state in India, is known for its rich tradition of utilizing local biodiversity for medicinal purposes. The state's diverse flora contributes significantly to traditional medicine practices, providing a reservoir of plants with potential antiviral properties that can be studied for their efficacy against diseases like COVID-19.

37) Ashvagandha (Asvagandha, Ashwagandha, Ashvagamdha, Ashva-gandha):
'Ashwagandha', or Withania somnifera, is an important herb in Ayurveda known for its adaptogenic and stress-relieving properties. Its examination in the context of immunological response during viral infections highlights the relevance of traditional knowledge in contemporary therapeutic strategies for improving health outcomes against diseases like COVID-19.

38) Developing:
'Developing' refers to the ongoing process of creating or formulating interventions, including drugs and vaccines, to combat diseases. In the context of COVID-19, developing new treatments and expanding existing research on herbal medicines reflect the urgency in addressing global health challenges through innovative approaches.

39) Harsingar:
'Harsingar', or Nyctanthes arbor-tristis, is significant in traditional medicine for its reputed health benefits. Researching its bioactive compounds provides insights into potential therapeutic applications, including antiviral properties, which could contribute to treating or preventing viral infections such as COVID-19.

40) Knowledge:
'Knowledge' encompasses the understanding and information gathered from research, studies, and traditional practices. It plays a fundamental role in advancing medical understanding and treatment strategies against diseases, particularly in bridging traditional remedies with modern medicine to combat widespread health challenges effectively.

41) Toxicity:
'Toxicity' relates to the degree to which a substance can harm organisms. In pharmacology, understanding and managing toxicity is crucial when developing new drugs, particularly in the context of balancing the benefits and risks of traditional versus synthetic remedies in treating viral infections like COVID-19.

42) Channel:
'Channels' often refers to pathways in the body through which signals and substances travel. In medicine, understanding these channels informs treatment strategies targeting various conditions, including viral infections, emphasizing the relevance of both modern pharmacological interventions and traditional herbal therapies.

43) Garlic:
Garlic, or Allium sativum, is a plant recognized for its medicinal properties, especially its potential to enhance immune responses and combat infections. Its inclusion in traditional medicine and modern dietary practices underscores the role of natural products in health promotion and disease prevention strategies, including against viral threats.

44) Powder:
'Powder' denotes a form of ground or crushed substance, often used in herbal medicine to facilitate administration and enhance bioavailability. The powder forms of medicinal herbs are essential in traditional formulations aimed at treating various diseases, promoting seamless integration of plant-based treatments in contemporary health care.

45) Tulsi:
'Tulsi', or Ocimum sanctum, is revered in Ayurveda for its health benefits, particularly its adaptogenic and immunomodulatory qualities. As a key herbal remedy in managing stress and infections, its utilization during viral pandemics underlines the importance of traditional herbs in boosting immunity and improving health outcomes.

46) Blood:
'Blood' is a vital fluid in the body, involved in the transport of nutrients, gases, and waste. Changes in blood components during infection, such as COVID-19, can inform health care practices and highlight the importance of maintaining optimal immune function through dietary and herbal interventions.

47) Genu:
'Genu' refers to the generation of structures or forms derived from organisms. In the context of medicinal plants, it implies the identification of morphological characteristics relevant for classification and studying the application of these plants in traditional or modern health solutions.

48) Tamil:
'Tamil' refers to the culture, language, and people in the Tamil Nadu region of India, where traditional medicine and herbal practices are prominent. The rich heritage of using local medicinal plants in Tamil culture contributes to understanding their efficacy in treating various ailments, including those related to viral diseases.

49) Nadu:
In the term 'Tamil Nadu', 'Nadu' refers to land or country, signifying the region of Tamil Nadu in India. The state's abundant biodiversity and traditional practices have led to significant herbal research, making it an important area for studying plant-based treatments for health issues such as COVID-19.

50) Pune:
Pune, a city in Maharashtra, is notable for its educational and pharmaceutical research institutions. As a hub for health care and traditional medicine studies, Pune contributes to advancing knowledge around herbal treatments and their potential roles in managing diseases, particularly those affecting respiratory health.

51) Neem:
'Neem', or Azadirachta indica, is a tree known for its various medicinal applications, particularly its anti-inflammatory and antimicrobial properties. Its potential in traditional medicine underlines the significance of exploring its constituents in the fight against diseases, especially those of viral origins, such as COVID-19.

52) Pain:
'Pain' is a complex symptom often associated with disease and injury, requiring careful management in medical practice. Understanding pain mechanisms enhances treatment strategies, including therapeutic approaches using herbal remedies that may provide relief without the side effects associated with conventional analgesics.

53) Azadirachta indica:
'Azadirachta indica', commonly known as neem, is celebrated for its diverse medicinal attributes, including antibacterial and antiviral actions. Its relevance in traditional medicine emphasizes the importance of natural products in addressing health challenges, such as viral infections, providing potential therapeutic avenues in integrated health care.

54) Withania somnifera:
'Withania somnifera', or ashwagandha, is an important adaptogen in Ayurvedic medicine, known for its stress-relieving and immune-boosting properties. Its studies signal the potential of traditional remedies in enhancing resilience against diseases, particularly during stress-related health crises such as viral outbreaks.

55) Adhatoda vasica:
'Adhatoda vasica', also known as Vasaka, is recognized for its expectorant and anti-inflammatory properties, making it prominent in traditional medicine for respiratory conditions. Its relevance in treating infections and promoting respiratory health highlights the need for research into herbal solutions for viral diseases like COVID-19.

56) Human body:
The 'human body' is the physical structure of a person, and understanding its functions is critical in developing health interventions. Knowledge of how the body responds to infections guides treatments, highlighting the importance of integrating natural and traditional remedies in supporting immune system health during epidemics.

57) Rasaushadhi (Rasa-aushadhi, Rasausadhi):
'Rasa-aushadhi' refers to the special formulations in Ayurveda that combine select herbs based on their rasas or essences. These preparations are designed to provide holistic health benefits, including enhancing immunity, and are vital for addressing conditions like COVID-19 through natural remedies.

58) Antibiotic (Antibacterial):
'Antibacterial' denotes substances that inhibit bacterial growth or kill bacteria. The study of antibacterial properties in various medicinal plants is crucial in the search for effective treatments against infections, showcasing the potential of traditional herbal remedies in modern therapeutics against bacterial and viral diseases.

59) Accumulation (Accumulating, Accumulate):
'Accumulate' refers to gathering or building up over time. In pharmacological contexts, understanding how compounds accumulate in the body can inform dosage regimens and safety profiles of both modern and herbal medicines used to treat infections and other diseases.

60) Yashtimadhu (Yastimadhu, Yashti-madhu):
'Yashtimadhu', or Glycyrrhiza glabra, is known in Ayurveda for its soothing properties, especially for respiratory ailments. Its active components provide anti-inflammatory effects, making it significant in natural medicine for supporting respiratory health during viral infections, highlighting its role in traditional health practices.

61) Mrityunjaya (Mrtyunjaya, Mrtyumjaya, Mrityumjaya):
'Mrityunjaya' is a term used to denote life-protecting or life-restoring therapies in Ayurvedic traditions. It represents a category of health practices aimed at enhancing vitality and wellness, reflecting the holistic approach of Ayurveda in combating diseases through natural substances and spiritual practice.

62) Alleviation:
'Alleviation' refers to the reduction of pain, discomfort, or severity of symptoms. In health care, the goal is to achieve alleviation through effective treatments, including natural remedies from traditional medicine that aim to ease conditions like those caused by viral infections.

63) Bhallataka:
'Bhallataka', or Semecarpus anacardium, is used in Ayurveda for its therapeutic properties, particularly in treating respiratory ailments. Recognizing its applications highlights how natural substances are valued in herbal medicine for their potential in supporting health initiatives, especially during health crises like viral epidemics.

64) Perception:
'Perception' refers to the awareness or understanding of a particular concept. In health care, the perception of herbal remedies as effective alternatives or complements to modern medicine impacts how treatments are administered and accepted, particularly during viral outbreaks like COVID-19.

65) Tamilnadu (Tamil-nadu):
'Tamil Nadu' is a state in India renowned for its rich cultural heritage and extensive use of traditional medicine. The state's diverse flora and practices contribute significantly to the understanding and application of herbal remedies in contemporary health care, especially in treating diseases like COVID-19.

66) Science (Scientific):
'Scientific' pertains to the systematic study of the natural world, emphasizing the use of research and empirical evidence to inform practices. The integration of scientific methods in researching herbal remedies can help establish their efficacy and safety profiles for treating diseases, thus bridging gaps between traditional and modern medicine.

67) Karnataka:
Karnataka is a state in India known for its rich diversity of medicinal herbs and traditional practices. Its vast botanical resources are invaluable for research into herbal treatments, contributing to Ayurvedic practices and enhancing the repertoire of natural solutions against diseases like COVID-19.

68) Sadvritta (Sadvrtta, Sat-vritta):
'Sadvritta' refers to ethical living and proper conduct in Ayurvedic philosophy, emphasizing holistic health. This principle underlines the importance of lifestyle in disease prevention and management, promoting the integration of traditional wisdom into modern health care strategies in addressing challenges like viral infections.

69) Samjivani (Sanjivani):
'Sanjivani' is an Ayurvedic term denoting life-giving or life-restoring herbs or formulations. These formulations aim to enhance vitality and support the immune system, especially during health crises, showcasing the significant role of traditional medicine in contemporary therapeutic approaches for managing diseases.

70) Himalaya (Hima-alaya):
Referring again to the Himalayan region, 'Himalaya' is significant for its biodiversity, which includes various medicinal plants essential for traditional health practices. Recognizing the region's contribution can lead to improved understanding and applications of herbal remedies in treating health issues such as COVID-19.

71) Haritaki:
'Haritaki', or Terminalia chebula, is a prominent herb in Ayurveda known for its health benefits, including digestive and respiratory health. Its incorporation into treatments illustrates the potential of traditional herbs in managing diseases, reinforcing the value of holistic approaches in health care, particularly during epidemics.

72) Triphala (Tri-phala):
'Triphala' is a traditional Ayurvedic formulation consisting of three fruits, utilized for its wide-ranging health benefits, including digestive support and immune enhancement. Its relevance in addressing health challenges, including those caused by viral infections, underscores the importance of integrating herbal remedies into modern health care practices.

73) Aushadhi (Ausadhi, Aushadhin, Ausadhin):
'Aushadhi' signifies herbal medicines or remedies in Ayurveda. The emphasis on aushadhi highlights the importance of integrating herbal treatments into current health care paradigms, particularly for managing infections and promoting wellness, aligning with a holistic approach to health you can derive from traditional systems.

74) Mutation:
'Mutation' refers to changes in the genetic structure of organisms, including viruses. Understanding mutation dynamics in viruses like SARS-CoV-2 is essential for epidemiology and vaccine development, underscoring the need for ongoing research into both antiviral agents and traditional herbal medicines' effectiveness against evolving pathogens.

75) Vitiation (Vitiated):
'Vitiated' indicates a state of imbalance or distortion within the body as per Ayurvedic principles, often leading to illness. Recognizing this concept is critical in traditional medicine approaches that aim to restore balance through dietary changes, herbal remedies, and lifestyle adjustments, particularly for managing infections.

[Note: The above list is limited to 75. Total glossary definitions available: 122]

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Natural product, Traditional medicine, Supportive treatment, Herbal medicine, Immune system, COVID-19 Pandemic, Viral Infection, Social distancing, Vaccine development, Phytoconstituent, Viral RNA synthesis, Quarantine strategies, Antiviral agent.

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