Diazepam-like effects of Acacia tortilis on mouse locomotion.
Journal name: World Journal of Pharmaceutical Research
Original article title: Diazepam like effects of herbal extract acacia tortilis growing in ksa on locomotor activity in mice
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Waheeb D. M Alharbi and Aisha Azmat
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Diazepam like effects of herbal extract acacia tortilis growing in ksa on locomotor activity in mice
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
1) IntroductionAcacia Tortilis, belonging to the Fabaceae family and commonly known as acacia gum, is a plant found in the Kingdom of Saudi Arabia. Various studies have indicated the plant's significant medicinal properties, including antimicrobial, analgesic, antioxidant, and anti-diabetic activities. However, there is limited scientific evaluation regarding its physiological and pharmacological effects, particularly concerning its impact on locomotor activities.
2) Effects of Acacia Tortilis on Locomotor Activity
The study investigated the influence of Acacia Tortilis leaf extract on the locomotor activity of mice using an open-field test. The aqueous extracts were prepared, and two different doses (400 mg/Kg and 800 mg/Kg) were administered via oral or intraperitoneal routes. Results indicated that the oral administration of both doses did not significantly alter locomotor activity, while the intraperitoneal administration of the higher dose (800 mg/Kg) resulted in a notable reduction in locomotion, comparable to the effects of the controlled substance Diazepam.
3) Comparison with Diazepam
The research highlighted a significant observation that the intraperitoneal administration of a high dose of Acacia Tortilis leads to decreased motor activity, establishing a similarity to the effects seen with Diazepam. Unlike the low doses of Acacia, which showed no significant influence on locomotion, the high doses indicate potential hypnotic or sedative-like properties that warrant further exploration.
4) Need for Further Research
The study suggests that the observed locomotor activity reduction at high doses of Acacia Tortilis necessitates further investigation. The findings underscore the importance of studying the effects of different dosage levels in various species to better understand the therapeutic potential of Acacia.
5) Conclusion
In conclusion, the findings of this study suggest that high doses of Acacia Tortilis extract administered intraperitoneally can significantly lower locomotor activity in mice, akin to the effects produced by Diazepam. These results open avenues for additional research into the pharmacological effects of Acacia Tortilis and its potential applications in medicinal practices.
FAQ section (important questions/answers):
What is the aim of the study on Acacia Tortilis?
The study aims to evaluate the effects of Acacia Tortilis leaf extract on locomotor activity in mice, exploring its potential as a safe and effective medicinal source.
How was the Acacia Tortilis extract prepared for the study?
The leaves were blended with distilled water, heated at 40掳C, then filtered to create a 100mg/ml aqueous extract for administering to the mice.
What doses of Acacia extract were administered to the mice?
Two doses of Acacia extract were used: 400mg/Kg and 800mg/Kg, administered either orally or intraperitoneally to evaluate locomotor activity.
What were the main findings of the locomotor activity tests?
The results showed that intraperitoneal administration of the 800mg/Kg dose significantly reduced locomotor activity, comparable to Diazepam, while lower doses administered orally had no significant effect.
What experimental methods were used to assess locomotor activity?
The open field test was employed, where the number of squares crossed and rearing behavior of mice were measured after administration of the Acacia extract.
What ethical guidelines were followed during the study?
The study adhered to the Guidelines for Care and Use of Laboratory Animals in Biomedical Research and received approval from the departmental ethics committee.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for 鈥淒iazepam-like effects of Acacia tortilis on mouse locomotion.鈥�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
Activity refers to the observable actions or behaviors exhibited by the mice during the locomotor tests in the study. Specifically, it measures the movement patterns and trends, such as how many squares the mice cross in an open field test, which is essential for evaluating the effects of Acacia Tortilis extracts.
2) Water:
Water serves as the solvent in the preparation of the Acacia Tortilis extract used in the study. It is critical for dissolving the active compounds in the plant leaves, allowing a thorough analysis of their effects on locomotor activity in mice. The use of distilled water ensures purity and consistency.
3) Drug:
Drug refers to a substance used to diagnose, cure, or prevent diseases or conditions. In this study, the Acacia Tortilis extract was evaluated for its potential drug-like effects on locomotor activity, especially in comparison to Diazepam, a known sedative drug. The classification of compounds as drugs is pivotal in pharmacological research.
4) Medicine:
Medicine is the science and practice of diagnosing, treating, and preventing illness. Acacia Tortilis is explored in this research for its potential medicinal properties, especially its effects on locomotor activity. Understanding its pharmacological effects can contribute to the development of alternative or complementary treatments in healthcare.
5) Science (Scientific):
Science is the systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions about the universe. This research exemplifies scientific inquiry, employing experimental methods to investigate the biological effects of Acacia Tortilis and advancing understanding within the field of natural product pharmacology.
6) Pharmacological:
Pharmacological pertains to the study of drugs and their effects on biological systems. This research assesses the pharmacological properties of Acacia Tortilis, examining how its extracts influence locomotor activity in mice. Understanding its pharmacological profile could support its potential therapeutic applications in clinical settings.
7) Antibiotic (Antibacterial):
Antibacterial describes the property of substances that actively inhibit or kill bacteria. Previous studies highlighted the antibacterial activities of Acacia Tortilis, suggesting its potential role in developing natural treatments. This characteristic is significant in the broader context of exploring plant extracts for various medicinal purposes and therapeutic interventions.
8) Phytochemical:
Phytochemical refers to the chemical compounds produced by plants, which may have bioactive effects. In this study, the leaves of Acacia Tortilis were analyzed for their phytochemical composition and potential impacts on locomotor activity. Understanding these compounds is essential for evaluating the plant鈥檚 medicinal uses and health benefits.
9) Discussion:
Discussion refers to the section of the study where the implications and interpretations of the results are analyzed. It provides insights into how the findings relate to existing literature, establishes the relevance of Acacia Tortilis on locomotor activity, and suggests directions for future research in pharmacology.
10) Diet:
Diet encompasses the food and drink consumed by the experimental animals. It is crucial to maintain a standard diet to ensure that any observed changes in locomotor activity can be attributed to the treatment with Acacia Tortilis rather than variations in nutritional intake, thereby ensuring the reliability of the study's results.
Other Science Concepts:
Discover the significance of concepts within the article: 鈥�Diazepam-like effects of Acacia tortilis on mouse locomotion.鈥�. Further sources in the context of Science might help you critically compare this page with similair documents:
Oral administration, Scientific analysis, Statistical Significance, Anti-inflammatory activity, Antioxidant activity, Antimicrobial activities, Ethics committee, Anti-inflammatory activities, Free radical scavenging, Antidepressant effect, Locomotor activity, Analgesic activities, Diazepam, Positive control, Anti-platelet activities, Animal house, Ethical approval, Open field test, Analgesic action, Intraperitoneal administration, High dose, Low dose, Spontaneous locomotor activity, Guidelines for Care and Use of Laboratory Animals, Laboratory animals, Cytotoxic activities, Competing interests, Anxiogenic effects, African Medicinal Plants.