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Glossary definitions and references:

Scientific and Ayurvedic Glossary list for 鈥淧rospective action plan on development of gastro retentive floating tablets鈥�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
Drug plays a central role in the development of gastro retentive floating tablets (GRFT). It refers to the active pharmaceutical ingredient that is intended to be absorbed in the stomach or duodenum, offering controlled or sustained release, improved bioavailability, and treating local gastric conditions such as ulcers and gastritis.

2) Ali (膧li, A岣丰阜i):
Alli refers to Dr. Saikh Mahammed Athar Alli, the primary author of the research paper published in the World Journal of Pharmaceutical Research. He is an Assistant Professor in the Department of Pharmaceutical Sciences at Shiats (Deemed to be University), Allahabad, Uttar Pradesh, India, specializing in GRFT.

3) Science (Scientific):
Science underpins the entire research and development process described in the article. It involves understanding the physiological, chemical, and material sciences required to design, formulate, and optimize gastro retentive floating tablets. Scientific principles guide experimental design, problem-solving, and development of robust and effective GRFT systems.

4) Knowledge:
Knowledge is a fundamental component for the research discussed. It refers to the extensive understanding required of gastrointestinal physiology, material properties, drug dissolution and absorption kinetics, and formulation strategies to successfully develop and optimize gastro retentive floating tablets with the desired performance characteristics.

5) Swelling:
Swelling is a crucial mechanism utilized in certain GRFTs to achieve an extended gastric residence time. Tablet formulations that swell upon contact with gastric fluids form a gel barrier, increasing their size to prevent premature exit from the stomach while controlling drug release.

6) Quality:
Quality in the context of GRFT relates to the reproducibility, consistency, and performance of the final product throughout its shelf life. It encompasses various evaluations such as floating time, buoyancy, specific gravity, drug content uniformity, mechanical properties, and in vitro and in vivo performance.

7) Salt (Salty):
Salt, particularly in the form of effervescent compounds like bicarbonate salts, is employed in certain GRFT formulations. These salts react with gastric acids to produce gas, facilitating the floating mechanism crucial for prolonging the tablets' gastric residence time and ensuring controlled drug release.

8) Substance:
Substance in this context mainly refers to the active pharmaceutical ingredients and excipients used in the formulation of GRFT. It includes polymers, gel-forming agents, effervescent materials, and other components that contribute to the desired characteristics of the floating tablets.

9) Transformation (Transform, Transforming):
Transform relates to the physicochemical interactions and processes that occur during the preparation and administration of GRFT. Transformational aspects include the conversion of materials into a gel barrier, generating buoyant forces through effervescence, and the transition of microparticles to a swollen state in the stomach.

10) Water:
Water or gastric fluid plays a significant role in the functioning of GRFT. Upon contact with water in the stomach, certain excipients in the tablet swell, hydrate, or react to form a gel barrier, enabling the tablet to float and release the drug in a controlled manner.

11) Ulcer:
Ulcer treatment is one of the medical applications of GRFT. These tablets are advantageous for locally acting drugs on gastric mucosa, providing therapeutic benefits in conditions like peptic ulcers by maintaining a prolonged drug residence in the stomach and ensuring targeted drug delivery at the ulcer site.