Study on Amrita Guggulu and Guduchi for Vatarakta (Gout) management
Journal name: Ayushdhara
Original article title: A Clinical Study to Evaluate the Effect of Amrita Guggulu and Guduchi Kwath in the Management of Vatarakta w.s.r. to Gout
AYUSHDHARA is an international peer-reviewed journal. It focuses on research in Ayurveda, Yoga, Unani, Siddha, Homeopathy, Allopathy, and Pharmaceutical Sciences.
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Vijay Chaudhary
Principal & H.O.D, P.G. Department of Kayachikitsa, R.G.G.P.G. Ayurveda College, Paprola, India.
Ankita Agrawal
Research Scholar, P.G. Department of Kayachikitsa, R.G.G.P.G. Ayurveda College, Paprola, India.
Ayushdhara:
(A peer-reviewed, bi-monthly open-access journal)
Full text available for: A Clinical Study to Evaluate the Effect of Amrita Guggulu and Guduchi Kwath in the Management of Vatarakta w.s.r. to Gout
Year: 2021 | Doi: 10.47070/ayushdhara.v8i5.809
Copyright (license): CC BY-NC-SA 4.0
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Summary of article contents:
Introduction
Gout, historically regarded as a "disease of kings," has seen a rise in prevalence across all socioeconomic groups due to dietary changes and sedentary lifestyles. It is a significant lifestyle disorder associated with increased visceral obesity and metabolic syndrome in contemporary society. In Ayurvedic terms, gout correlates to "Vatarakta," characterized by an imbalance of Vata dosha and the involvement of Rakta dushya. This study aimed to evaluate the effectiveness and safety of Ayurvedic treatments—specifically, Amrita Guggulu and Guduchi Kwath—in managing Vatarakta, utilizing both classical Ayurvedic symptoms and modern diagnostic tools such as serum uric acid levels.
Pathophysiology and Symptoms of Vatarakta
In Vatarakta, the overconsumption of incompatible foods and a sedentary lifestyle lead to aggravated Vata and disturbed Rakta dhatu, provoking a series of pathophysiological reactions. Patients typically experience classical symptoms including joint pain (Sandhi Shoola), swelling (Sandhi Shotha), tenderness (Sparsha Asahyata), and others. A total of 15 patients participated in the study, diagnosed based on both Ayurvedic clinical signs and serum uric acid levels. The outcomes revealed that all patients exhibited significant symptoms of Vatarakta, corroborating the understanding of this condition as one driven by dietary and lifestyle factors.
Effective Treatment and Results
The trial administered Amrita Guggulu (1 gram) and Guduchi Kwath (50 ml) twice a day for 45 days, alongside lifestyle modifications. The results showed marked improvements�28.57% of patients experienced significant relief, while 50% showed moderate improvement. Objective measures displayed a 34.29% reduction in mean serum uric acid levels, indicating a favorable response to the treatment. Additionally, no adverse effects were reported, affirming the safety of the Ayurvedic formulation for managing gout.
Conclusion
The study concluded that Amrita Guggulu and Guduchi Kwath effectively manage Vatarakta, demonstrating significant improvements in both subjective symptoms and objective uric acid levels. The combination of these Ayurvedic treatments not only alleviated pain and inflammation but also contributed to reducing high serum uric acid, thus addressing both the immediate discomfort and underlying causes of gout. Given the promising outcomes, further research on larger cohorts over extended durations is recommended to validate these results and enhance treatment modalities for gout in modern clinical practice.
FAQ section (important questions/answers):
What was the focus of the clinical study conducted?
The study evaluated the effects of Amrita Guggulu and Guduchi Kwath in managing Vatarakta, commonly associated with gout. It aimed to assess their efficacy and safety in reducing symptoms and serum uric acid levels in patients.
How many patients participated in the clinical trial?
A total of 15 patients diagnosed with Vatarakta were selected for the trial. The patients were treated for 45 days and regularly assessed for improvements in symptoms and serum uric acid levels throughout the study.
What were the main outcomes of the trial?
The trial showed significant improvements in joint pain, swelling, and tenderness. Additionally, serum uric acid levels decreased substantially, indicating the effectiveness of the trial drugs in managing Vatarakta without reported adverse effects.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Study on Amrita Guggulu and Guduchi for Vatarakta (Gout) management�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
In the context of the study, 'drug' refers to the herbal formulations used to manage Vatarakta or gout. These include Amrita Guggulu and Guduchi Kwath which were given to patients to assess their effectiveness in reducing symptoms such as joint pain and swelling.[see source text or glossary: Drug]
2) Vatarakta (Vata-rakta):
Vatarakta is an Ayurvedic concept often correlated with gout in modern medicine. It involves the vitiation of Vata and Rakta Doshas, leading to symptoms like pain, swelling, and redness in the joints. It's treated with therapies aimed at pacifying these doshas.[see source text or glossary: Vatarakta]
3) Disease:
In the study, disease refers to the condition being treated, primarily Vatarakta (gout). This disorder manifests as inflammatory arthritis, characterized by sudden severe attacks of pain, redness, and tenderness in joints, often at the base of the big toe.[see source text or glossary: Disease]
4) Guggulu:
Guggulu is a resin widely used in Ayurvedic medicine, particularly in the formulation of Amrita Guggulu. It has anti-inflammatory properties and is used to treat various inflammatory disorders including Vatarakta by pacifying the vitiated Vata and Rakta doshas.[see source text or glossary: Guggulu]
5) Pain:
Pain, or Sandhi Shoola, is a primary symptom of Vatarakta, particularly gout. The study uses this symptom to evaluate the efficacy of treatments like Amrita Guggulu and Guduchi Kwath, observing significant reductions in pain levels among participants.[see source text or glossary: Pain]
6) Swelling:
Swelling or Sandhi Shotha is one of the cardinal symptoms of Vatarakta. The study evaluates the effectiveness of Amrita Guggulu and Guduchi Kwath by measuring the change in joint swelling before and after the treatment.[see source text or glossary: Swelling]
7) Stiffness:
Stiffness, referred to as Stabdhata, is a common symptom in Vatarakta (gout). It is used as a subjective criterion to evaluate the effectiveness of the trial drugs in the study, showing a significant reduction in stiffness after treatment.[see source text or glossary: Stiffness]
8) Sandhi (Shandhi, Samdhi):
Sandhi means 'joint' in Sanskrit. In this study, various Sandhi, such as MTP (metatarsophalangeal), knee, and elbow joints, are examined for symptoms like pain (Shoola) and swelling (Shotha) to assess the effects of the trial drugs on Vatarakta.[see source text or glossary: Sandhi]
9) Amrita (Amrta):
Amrita, often referring to Guduchi (Tinospora cordifolia), is a primary ingredient in Amrita Guggulu. It has immunomodulatory and anti-inflammatory properties, making it effective in treating conditions like Vatarakta by reducing symptoms such as pain and swelling.[see source text or glossary: Amrita]
10) Burning sensation:
Burning sensation, or Vidaha, is one of the symptoms evaluated in the study of Vatarakta patients. The intensity of burning sensation was measured to determine the efficacy of the trial drugs, Amrita Guggulu and Guduchi Kwath, in alleviating this symptom.[see source text or glossary: Burning sensation]
11) Amalaki:
Amalaki, or Emblica officinalis, is one of the key ingredients in Amrita Guggulu. Known for its anti-inflammatory and antioxidant properties, Amalaki helps in the detoxification process and reduces the symptoms associated with Vatarakta.[see source text or glossary: Amalaki]
12) Dosha (Dosa):
Dosha refers to the three fundamental bodily bio-elements in Ayurveda: Vata, Pitta, and Kapha. In the case of Vatarakta, Vata Dosha and Rakta (blood) are primarily vitiated, causing symptoms like pain, swelling, and redness in the joints.[see source text or glossary: Dosha]
13) Rakta:
Rakta or blood is one of the primary elements involved in the pathology of Vatarakta. Vitiation of Rakta along with Vata leads to symptoms such as inflammation, pain, and swelling in joints, which the trial drugs aim to mitigate.[see source text or glossary: Rakta]
14) Vata:
Vata is one of the three doshas in Ayurveda responsible for movement and bodily functions. In Vatarakta, the Vata dosha is aggravated alongside Rakta, leading to symptoms like joint pain, stiffness, and inflammation.[see source text or glossary: Vata]
15) Haritaki:
Haritaki, or Terminalia chebula, is an ingredient in Amrita Guggulu. It has laxative, antioxidant, and anti-inflammatory properties, aiding in the detoxification process and the management of Vatarakta symptoms.[see source text or glossary: Haritaki]
16) Dhatu:
Dhatu refers to the bodily tissues in Ayurvedic medicine. In Vatarakta, Rakta Dhatu (blood tissue) is primarily involved alongside Vata. The treatment aims to restore balance to these Dhatus, thereby alleviating the symptoms of the disease.[see source text or glossary: Dhatu]
17) Food:
In the study, diet plays a crucial role in the management of Vatarakta. Patients are advised to follow a low-protein diet and avoid foods that can aggravate Vata and increase uric acid levels, such as meat, alcohol, and high-purine foods.[see source text or glossary: Food]
18) Diet:
Dietary habits are significant in the management of Vatarakta. Patients in the study were advised to avoid high-protein foods, alcohol, and other dietary factors that can exacerbate the condition, while following a regimen that supports treatment.[see source text or glossary: Diet]
19) Raktadhatu (Rakta-dhatu):
Rakta-dhatu, the blood tissue, is primarily involved in the pathology of Vatarakta. The study aims to balance Rakta-dhatu through the use of herbal formulations like Amrita Guggulu and Guduchi Kwath, thereby treating symptoms like redness and inflammation.[see source text or glossary: Rakta-dhatu]
20) Pippali (Pippalin):
Pippali, or Piper longum, is an ingredient in Amrita Guggulu known for its digestive and anti-inflammatory properties. It helps in alleviating symptoms of Vatarakta, such as pain and swelling, by improving digestion and reducing inflammation.[see source text or glossary: Pippali]
21) Vidaha:
Vidaha, or burning sensation, is a symptom of Vatarakta. The study measures the effectiveness of Amrita Guggulu and Guduchi Kwath in reducing Vidaha, showing statistically significant improvement in patients after treatment.[see source text or glossary: Vidaha]
22) Raga:
Raga refers to redness, a symptom of Vatarakta observed in inflamed joints. The study evaluates the reduction of Raga to determine the effectiveness of the trial drugs, which showed a significant decrease in redness among patients.[see source text or glossary: Raga]
23) Rasayana (Rasa-ayana):
Rasayana refers to rejuvenative therapies in Ayurveda. Ingredients like Guduchi and Amalaki in the trial drugs possess Rasayana properties, which help in maintaining homeostasis and improving overall health while treating Vatarakta.[see source text or glossary: Rasayana]
24) Vidanga (Vidamga):
Vidanga, or Embelia ribes, is an ingredient in Amrita Guggulu. Known for its antimicrobial and anti-inflammatory properties, Vidanga helps in detoxifying the body and reducing the symptoms of Vatarakta, such as pain and swelling.[see source text or glossary: Vidanga]
25) Sparsha (Sparsa):
Sparsha, meaning touch or tenderness, is used as a subjective criterion in the study to evaluate the effectiveness of the trial drugs in reducing joint tenderness in Vatarakta patients.[see source text or glossary: Sparsha]
26) Dravya:
Dravya means substance or material. In this study, different herbal Dravyas like Guduchi, Haritaki, and Amalaki are components of Amrita Guggulu and Guduchi Kwath used to treat Vatarakta.[see source text or glossary: Dravya]
27) Shotha (Sotha):
Shotha, meaning swelling, is a key symptom of Vatarakta. The study measures Shotha to assess the efficacy of the trial drugs, Amrita Guggulu and Guduchi Kwath, in reducing joint swelling.[see source text or glossary: Shotha]
28) Family:
Family history is an observational factor in the study. Some patients with Vatarakta had a family history of gout, indicating a potential genetic link or shared lifestyle factors contributing to the disease.[see source text or glossary: Family]
29) Bibhitaka:
Bibhitaka, or Terminalia bellirica, is an Ayurvedic herb used in Amrita Guggulu. It has anti-inflammatory and detoxifying properties, aiding in the management of symptoms like pain and swelling in Vatarakta patients.[see source text or glossary: Bibhitaka]
30) Triphala (Tri-phala):
Triphala, a combination of Amalaki, Haritaki, and Bibhitaka, is an ingredient in Amrita Guggulu. It works as a Xanthine Oxidase inhibitor, similar to Allopurinol, and helps in reducing uric acid levels in Vatarakta patients.[see source text or glossary: Triphala]
31) Tikshna (Tiksna):
Tikshna, meaning sharp or intense, refers to the properties of certain Ayurvedic drugs. In the study, ingredients with Tikshna properties like Guggulu and Guduchi help in dissolving deeply embedded toxins and facilitating their removal.[see source text or glossary: Tikshna]
32) Karma (Karman):
Karma refers to action or function. In the context of the study, it relates to the therapeutic actions of the trial drugs, such as anti-inflammatory, analgesic, and detoxifying effects, which help in managing Vatarakta symptoms.[see source text or glossary: Karma]
33) Danti (Dantin, Damti):
Danti, or Baliospermum montanum, is an ingredient in Amrita Guggulu. It has strong purgative properties that help in the detoxification process, reducing the symptoms of Vatarakta by aiding in the elimination of toxins.[see source text or glossary: Danti]
34) Ushna (Usna):
Ushna, meaning hot, refers to the quality of certain Ayurvedic ingredients. Many ingredients in Amrita Guggulu, like Shunthi and Pippali, have Ushna virya (hot potency), which helps in pacifying Vata dosha and reducing pain and inflammation in Vatarakta.[see source text or glossary: Ushna]
35) Guna:
Guna refers to the qualities or attributes of substances. In the study, the trial drugs possess various Gunas such as anti-inflammatory, analgesic, and Rasayana (rejuvenating) properties, which help in the management of Vatarakta.[see source text or glossary: Guna]
36) Tinospora cordifolia:
Tinospora cordifolia, also known as Guduchi, is a prominent ingredient in both Amrita Guggulu and Guduchi Kwath. It has immunomodulatory, anti-inflammatory, and detoxifying properties, making it effective in treating Vatarakta.[see source text or glossary: Tinospora cordifolia]
37) Emblica officinalis:
Emblica officinalis, commonly known as Amalaki, is used in Amrita Guggulu. It has antioxidant, anti-inflammatory, and rejuvenating properties, helping in the detoxification process and the management of Vatarakta symptoms like pain and swelling.[see source text or glossary: Emblica officinalis]
38) Terminalia chebula:
Terminalia chebula, or Haritaki, is an ingredient in Amrita Guggulu. Known for its laxative, antioxidant, and anti-inflammatory properties, it aids in detoxification and helps alleviate symptoms of Vatarakta, such as joint pain and swelling.[see source text or glossary: Terminalia chebula]
39) Inflammation:
Inflammation is a key feature of Vatarakta, characterized by swelling, redness, and pain in the joints. The study measures the reduction in inflammation to evaluate the efficacy of Amrita Guggulu and Guduchi Kwath in treating Vatarakta.[see source text or glossary: Inflammation]
40) Vatashonita (Vatasonita, Vata-shonita):
Vatashonita is another term for Vatarakta in Ayurvedic texts, indicating the involvement of vitiated Vata and Rakta. The study focuses on alleviating symptoms of Vatashonita using Ayurvedic formulations like Amrita Guggulu and Guduchi Kwath.[see source text or glossary: Vatashonita]
41) Vatadosha (Vatadosa, Vata-dosha):
Vatadosha is the dosha responsible for movement and activity in the body. In Vatarakta, aggravated Vatadosha leads to symptoms like joint pain and stiffness. The study aims to pacify Vatadosha using Amrita Guggulu and Guduchi Kwath.[see source text or glossary: Vatadosha]
42) Vaivarṇya (Vaivarnya, Vaivanrya):
Vaivarnya refers to discoloration of the skin, a symptom of Vatarakta. The study evaluates the effectiveness of the treatment by measuring changes in skin discoloration in affected joints.[see source text or glossary: Vaivarnya]
43) Ayurveda (Ayus-veda):
Ayurveda is the traditional Indian system of medicine. The study employs Ayurvedic principles and formulations, such as Amrita Guggulu and Guduchi Kwath, to manage Vatarakta by addressing the underlying doshic imbalances.[see source text or glossary: Ayurveda]
44) Medicine:
In this study, medicine refers to the Ayurvedic formulations used to treat Vatarakta. Amrita Guggulu and Guduchi Kwath are the medicines tested for their efficacy in reducing symptoms like pain, swelling, and stiffness in gout patients.[see source text or glossary: Medicine]
45) Samhita:
Samhita refers to classical Ayurvedic texts. The study draws on treatments for Vatarakta mentioned in Samhitas, such as internal and external therapies to pacify aggravated doshas and alleviate symptoms like inflammation and redness.[see source text or glossary: Samhita]
46) Shunthi (Sunthi, Sumthi, Shumthi):
Shunthi, or dried ginger (Zingiber officinale), is an ingredient in Amrita Guggulu. It has anti-inflammatory and digestive properties, helping to pacify Vata and reduce symptoms like pain and inflammation in Vatarakta patients.[see source text or glossary: Shunthi]
47) Dushya (Dusya):
Dushya refers to the bodily tissues that get affected in a disease. In Vatarakta, the Dushyas primarily involved are Rakta (blood) and the joints, which become vitiated along with Vata dosha, leading to symptoms like swelling and pain.[see source text or glossary: Dushya]
48) Vihara:
Vihara refers to lifestyle and habits. In the study, patients were advised to avoid certain Vihara like consuming alcohol, practicing Visma-asana (improper postures), and Nidra vipryaya (inappropriate sleep patterns) to manage Vatarakta effectively.[see source text or glossary: Vihara]
49) Nature:
In the context of the study, nature refers to the characteristics and behaviors of the disease Vatarakta as well as the herbal formulations used. The drugs have natural anti-inflammatory and analgesic properties that help in treating the disease.[see source text or glossary: Nature]
50) Pulse:
Pulse is one of the dietary factors considered in the study. Patients with Vatarakta were advised to avoid pulses with intact outer coats, which can aggravate Vata and contribute to the symptoms of the disease.[see source text or glossary: Pulse]
51) Blood:
Blood, or Rakta, is a key element involved in Vatarakta. The study measures serum uric acid levels in the blood to assess the effectiveness of the treatment in lowering uric acid, a primary cause of the symptoms observed in Vatarakta.[see source text or glossary: Blood]
52) Tvak:
Tvak, or Cinnamon cardamom, is an ingredient in Amrita Guggulu. It is known for its anti-inflammatory and digestive properties, aiding in the reduction of pain and swelling in patients with Vatarakta.[see source text or glossary: Tvak]
53) Kala:
Kala, meaning time or era, is used to describe different periods in Ayurvedic texts. The reference to 'Vedic Kala' indicates the ancient times when specific diseases like Vatarakta were documented and treated with traditional Ayurvedic methods.[see source text or glossary: Kala]
54) Commiphora mukul:
Commiphora mukul, also known as Guggulu, is a resin used in Amrita Guggulu. It has potent anti-inflammatory and lipid-lowering properties, helping to manage symptoms of Vatarakta by pacifying Vata dosha and reducing inflammation.[see source text or glossary: Commiphora mukul]
55) Pharmacological:
Pharmacological refers to the study of drugs and their effects on the body. The study explores the pharmacological actions of Ayurvedic formulations like Amrita Guggulu and Guduchi Kwath, which include anti-inflammatory and analgesic effects in Vatarakta management.[see source text or glossary: Pharmacological]
56) Vedanasthapana (Vedana-sthapana):
Vedanasthapana refers to pain-relieving properties. Many ingredients in the trial drugs, like Guduchi and Guggulu, possess Vedanasthapana qualities, which help in reducing the pain associated with Vatarakta.[see source text or glossary: Vedanasthapana]
57) Embelia ribes:
Embelia ribes, known as Vidanga, is an ingredient in Amrita Guggulu. It has antiparasitic and anti-inflammatory properties, aiding in detoxification and reducing symptoms like joint pain and swelling in Vatarakta.[see source text or glossary: Embelia ribes]
58) Tridoshahara (Tridosahara, Tridosha-hara):
Tridoshahara refers to the property of balancing all three doshas (Vata, Pitta, and Kapha). The trial drugs used in the study possess Tridoshahara properties, which help in the overall management of Vatarakta by harmonizing the bodily doshas.[see source text or glossary: Tridoshahara]
59) Shothaghna (Sothaghna, Shotha-ghna):
Shothaghna refers to anti-inflammatory properties. Ingredients in Amrita Guggulu, like Guduchi and Guggulu, possess Shothaghna qualities that help in reducing the swelling and inflammation in joints affected by Vatarakta.[see source text or glossary: Shothaghna]
60) Discussion:
Discussion in the study revolves around the analysis of data collected regarding the efficacy and safety of the trial drugs, Amrita Guggulu and Guduchi Kwath, in managing Vatarakta by reducing symptoms like pain, swelling, and serum uric acid levels.[see source text or glossary: Discussion]
[Note: The above list is limited to 75. Total glossary definitions available: 93]
Other Science Concepts:
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Vatarakta, Triphala, Tridoshahara, Adverse effect, Sedentary lifestyle, Joint involvement, Clinical trial, Clinical Signs and Symptoms, Ethical committee approval, Metabolic syndrome, Dosha and Dushya, Lifestyle disorder, Amrita guggulu, Dietary habit, Serum Uric Acid, Risk factor, Pharmacological agent, H.O.D., Guduchi Kwath.