Sedative Hypnotic Activity of Manahshila (Realgar) -An Experimental Evaluation
Journal name: Ancient Science of Life
Original article title: Sedative Hypnotic Activity of Manahshila (Realgar) -An Experimental Evaluation
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Naveena Kodlady, M. S. Doddamani, Y. Vishwanath, B. J. Patgiri
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Sedative Hypnotic Activity of Manahshila (Realgar) -An Experimental Evaluation
Year: 2011
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
Manahshila, commonly known as Realgar or Arsenic Disulphide, is a significant component of traditional Ayurvedic medicine, utilized for its therapeutic properties for centuries. It is primarily indicated for various ailments, including skin diseases, respiratory issues, and psychological disorders. Recognized as a potent Rasayana (rejuvenator), Manahshila is believed to possess various pharmacological benefits, including sedative and hypnotic effects. Recent experimental evaluations aim to better understand these effects, particularly in the context of modern pharmacological assessments.
Sedative Hypnotic Activity of Manahshila
The study conducted on the sedative hypnotic activity of Manahshila involved administering purified Manahshila known as Ardraka Shodhita Manahshila (ASM) to albino rats, measuring its effects on spontaneous motor activity (SMA) and diazepam-induced sleep. The results indicated a statistically significant reduction in SMA across various time intervals post-administration, suggesting a pronounced sedative effect of ASM when compared to control groups. Notably, after 60 minutes of receiving ASM, the rats demonstrated a significant reduction in motor activity, outperforming both the control and standard diazepam groups at later intervals as well. Additionally, ASM treatment resulted in an earlier onset of sleep and prolonged sleep duration when combined with diazepam, indicating its potential to enhance hypnotic effects.
Conclusion
The findings from the experimental evaluations highlight the sedative hypnotic properties of Manahshila, supporting its traditional use in managing psychological disorders and insomnia. The significant reduction in spontaneous motor activity and the enhancement of sedative effects when used in conjunction with diazepam affirm the compound's efficacy. This research reinforces the need for further investigations into the mechanisms underlying Manahshila's action, particularly its interaction with neurotransmitters, to fully elucidate its therapeutic potential within Ayurvedic medicine. Future studies may expand upon this foundational work to explore the broader applicability of Manahshila in modern therapeutic contexts.
FAQ section (important questions/answers):
What is Manahshila and its traditional uses in Ayurveda?
Manahshila, or Realgar, is an arsenical compound used in Ayurveda for treating skin, respiratory, and psychological disorders. It's also known for its applications in formulations aimed at sedative, antipyretic, and anti-inflammatory treatments.
What were the objectives of the experimental evaluation of Manahshila?
The evaluation aimed to assess the sedative hypnotic activity of Manahshila through tests on spontaneous motor activity in rats and its effect on diazepam-induced sleeping time.
How was Manahshila prepared for the experimental study?
Manahshila was purified using a process called Shodhana, specifically by levigating with ginger juice for seven times, ensuring its medicinal usage was safe and effective.
What were the main findings from the study on Manahshila?
The study found significant sedative hypnotic effects of Ardraka Shodhita Manahshila, evidenced by reduced spontaneous motor activity in rats and increased sleeping time when combined with diazepam.
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Haratala, Jvara (fever), Shodhana purification, Pharmacological evaluation, Statistically significant reduction, Experimental evaluation, Vata-Kaphahara, Psychological disorder, Ayurvedic classic, Actophotometer, Manahshila (Realgar), Sedative Hypnotic Activity.