ANTI INFLAMMATORY ACTIVITY OF CONE VOLA TILE OIL OF CUPRESSUS FUNEBRIS Endl
Journal name: Ancient Science of Life
Original article title: ANTI INFLAMMATORY ACTIVITY OF CONE VOLA TILE OIL OF CUPRESSUS FUNEBRIS Endl
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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SI Manimaran, B.S. Ashok Kumar, Salemulla Khan, Durgesh Patel, B. Suresh
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: ANTI INFLAMMATORY ACTIVITY OF CONE VOLA TILE OIL OF CUPRESSUS FUNEBRIS Endl
Year: 2005
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
The study investigates the anti-inflammatory activity of volatile oil extracted from the cones of Cupressus funebris, commonly known as Chinese weeping cypress or funeral cypress. This tree, native to central China, has also been widely cultivated in the Himalayas, Sikkim, Nepal, and South Indian hill stations. The research employs the carrageenan-induced paw oedema model in albino mice to assess the anti-inflammatory effects of the oil, comparing its effects with those of Diclofenac sodium, a standard anti-inflammatory drug.
Mechanism of Anti-Inflammatory Activity
The volatile oil from Cupressus funebris was tested using a controlled experimental setup. Adult albino rats were divided into three groups: a control group receiving Tween-80, a standard group receiving Diclofenac sodium at 25 mg/kg, and a test group receiving the essential oil at 100 mg/kg. Measurements of paw volume were taken before and after the injection of carrageenan to evaluate the anti-inflammatory responses. The results showed a significant reduction in paw edema at the first and second hours post-injection, with the volatile oil exhibiting a percentage inhibition of 58% and 49% compared to 68% and 64% for Diclofenac sodium. This indicates that the volatile oil significantly inhibits inflammation, particularly during the second phase attributed to the release of inflammatory mediators such as cytokines and prostaglandins.
Conclusion
The findings of this study highlight the promising anti-inflammatory properties of the volatile oil from Cupressus funebris. The experimental results suggest that it acts effectively in reducing inflammation, especially in response to carrageenan-induced edema, making it a candidate for further research into its therapeutic potential. Given the oil's significant inhibition rates compared to the standard drug, it warrants deeper investigation to explore its applications in pharmacotherapy for inflammatory conditions.
FAQ section (important questions/answers):
What is the source of the volatile oil studied?
The volatile oil was obtained from the cones of Cupressus funebris, commonly known as Chinese weeping cypress, through hydrodistillation.
What was the method used to measure anti-inflammatory activity?
The anti-inflammatory activity was assessed using the carrageenan-induced paw edema model in adult albino rats, measuring paw volume changes after administering the oil.
How effective was the volatile oil compared to Diclofenac sodium?
The volatile oil exhibited significant anti-inflammatory activity, showing 58% and 49% inhibition at specific hours compared to Diclofenac sodium鈥檚 68% and 64% inhibition.
What conclusions were drawn about the oil's effects?
The study concluded that the volatile oil from Cupressus funebris possesses significant anti-inflammatory properties, particularly during the second phase of carrageenan-induced edema.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for 鈥淎NTI INFLAMMATORY ACTIVITY OF CONE VOLA TILE OIL OF CUPRESSUS FUNEBRIS Endl鈥�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
The term 'Activity' refers to the functional role of the volatile oil derived from the cones of Cupressus funebris in demonstrating anti-inflammatory effects. In the study, this activity was assessed through an established protocol using carrageenan-induced paw edema in rats, showcasing its potential therapeutic applications in inflammation management.
2) Edema (Oedema):
'Oedema' is synonymous with edema and specifically describes the fluid accumulation effects in a biological context, particularly in the rat paw during the experiment. The study's emphasis on measuring oedema reduction through the application of volatile oil provides valuable insights into its potential therapeutic roles in similar inflammatory conditions.
3) Drug:
'Drug' refers to substances used for medical treatment, specifically the standard anti-inflammatory agent Diclofenac sodium in the study. It served as a comparative benchmark to evaluate the efficacy of the volatile oil from Cupressus funebris, which offers insights into herbal alternatives for pain and inflammation relief.
4) Inflammation:
'Inflammation' is a biological response characterized by swelling, redness, and pain, often due to tissue injury or infection. The study specifically investigates the anti-inflammatory properties of the volatile oil, establishing its relevance in reducing inflammation-related symptoms by inhibiting responses in a controlled experimental setup.
5) Substance:
'Substance' refers to any material with defined properties. In the context of the study, the volatile oil extracted from Cupressus funebris is the focus. The research evaluates its chemical properties and biological significance in providing an alternative therapeutic option for inflammation, thereby underscoring its importance in medicinal contexts.
6) Discussion:
'Discussion' represents the critical analysis and interpretation of data presented in the study. This section elaborates on the implications of the findings regarding the volatile oil's anti-inflammatory activity, placing it within the broader context of herbal medicine and its efficacy compared to conventional pharmaceuticals, as well as future research directions.
7) Science (Scientific):
'Science' signifies the comprehensive body of knowledge formed through rigorous inquiry and empirical evidence. In this study, the exploration of the anti-inflammatory properties of Cupressus funebris represents the intersection of traditional herbal remedies and modern scientific methods, fostering the advancement of pharmacological understanding and innovations in healthcare.
8) Himalaya (Him膩laya, Hima-alaya):
'Himalaya' denotes the geographical region where Cupressus funebris is cultivated and studied. This region's unique climatic and ecological conditions contribute to the growth of specific flora, including medicinal plants. Understanding the environmental significance of the Himalayas is crucial in assessing the sourcing and potential therapeutic contributions of native plant species.
9) Palani (P膩lan墨, Pazhani):
'Palani' refers to a district in India, part of the region studied for its biodiversity and medicinal plants. The inclusion of local flora, like Cupressus funebris, highlights the potential of regional species in contributing to alternative medicine practices, thereby enriching pharmacognosy and promoting sustainable use of indigenous resources.
10) Water:
'Water' is a fundamental solvent used in various biological and chemical processes, including the extraction of volatile oils through hydrodistillation. The study underscores the necessity of water in yielding the volatile oil from Cupressus funebris and signifies its importance in preparing herbal remedies and evaluating their properties for therapeutic use.
11) Cina (C墨na, C墨n膩, Ci峁塧, Ci峁壞�, C墨峁壞�, Cin膩):
'China' denotes the native habitat of Cupressus funebris, emphasizing its historical and geographical significance. The study's findings relating to the plant's properties not only contribute to understanding this species' therapeutic applications but also underscore the importance of preserving biodiversity in its native regions for future medicinal exploration.
Other Science Concepts:
Discover the significance of concepts within the article: 鈥�ANTI INFLAMMATORY ACTIVITY OF CONE VOLA TILE OIL OF CUPRESSUS FUNEBRIS Endl鈥�. Further sources in the context of Science might help you critically compare this page with similair documents:
Anti-inflammatory activity, Plant material, Histamine and serotonin, Carrageenan-induced paw edema, Diclofenac sodium, Volatile oil, Hydrodistillation, Percentage of inhibition, Paw edema, Standard laboratory condition, Albino rat.