Evaluating rudraksha's effect on adrenaline and nicotine hypertension.
Journal name: Ancient Science of Life
Original article title: An experimental evaluation of the effect of rudraksha (elaeocarpus ganitrus roxb) in adrenaline and nicotine induced hypertension
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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Dr Jayantha Kumar Sarma, Dr G.C. Bhuyan, Dr (Mrs) Jyotika Koley, L. N Maity, Dr V. B. Naikwadi
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: An experimental evaluation of the effect of rudraksha (elaeocarpus ganitrus roxb) in adrenaline and nicotine induced hypertension
Year: 2004
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
This study investigates the effects of Rudraksha (Elaeocarpus ganitrus Roxb) on hypertension induced by adrenaline and nicotine in an experimental setting. The research was conducted on six anaesthetized cats of similar age and body weight. The focus was to evaluate how the 90% ethanol extract of Rudraksha affects blood pressure, which is critical considering the growing prevalence of hypertension globally. Previous Ayurvedic practices suggested the utility of Rudraksha in managing various ailments, including conditions analogous to modern hypertension. This experimental approach aims to scientifically validate these claims amidst an era of rapid advancements in biomedical research.
Effect of Rudraksha on Hypertension
The study reveals a significant hypotensive effect of the ethanol extract of Elaeocarpus ganitrus Roxb when administered intravenously to anaesthetized cats. It was found that the extract effectively reduced normal blood pressure from an average of 86.94 mmHg to 73.43 mmHg, which was statistically significant. Notably, the extract completely counteracted adrenaline-induced hypertension, indicating its potential efficacy in managing stress-related blood pressure increases. Conversely, the extract did not demonstrate similar effectiveness against nicotine-induced hypertension, which poses a complex challenge due to nicotineâs stimulatory effects on the sympathetic nervous system.
Conclusion
The findings suggest that Elaeocarpus ganitrus Roxb exhibits a hypotensive effect, particularly against adrenaline-induced hypertension, while proving ineffective for nicotine-induced elevation in blood pressure. This indicates that while Rudraksha may have therapeutic potential in stress-related hypertension scenarios, its utility may not extend to all hypertension types, especially those associated with smoking. These results endorse the assertion that traditional herbal medicines could offer viable alternatives in hypertension management, warranting further research for application in clinical settings. This study underlines the importance of methodical evaluation of Ayurvedic remedies through rigorous scientific methodologies.
FAQ section (important questions/answers):
What is the aim of the study on Rudraksha?
The study investigates the effects of Rudraksha (Elaeocarpus ganitrus Roxb) on experimentally induced acute hypertension using adrenaline and nicotine in anaesthetized cats.
How was hypertension induced in the experimental animals?
Acute hypertension was induced in the cats using intravenous administration of nicotine and adrenaline, which stimulate the sympathetic nervous system and increase blood pressure.
What were the findings regarding Rudraksha's effect on hypertension?
Rudraksha significantly reduced adrenaline-induced hypertension but was ineffective against nicotine-induced hypertension. The extract lowered blood pressure in treated animals.
What potential applications does Rudraksha have in medicine?
Rudraksha may be considered a safer alternative for managing stress-induced hypertension, but it is not effective for hypertension typically seen in smokers.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for âEvaluating rudraksha's effect on adrenaline and nicotine hypertension.â�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Blood:
Blood is a vital fluid in living organisms that transports oxygen and nutrients while removing waste. In this study, blood pressure measurements are crucial for evaluating the effects of the Rudraksha extract on induced hypertension, exemplifying how changes in blood pressure can indicate drug efficacy and health status.
2) Drug:
A drug is a substance used for medical treatment. This study investigates the antihypertensive properties of the ethanol extract of Rudraksha. Understanding the drug's effects on biological systems helps legitimize herbal medicine within the framework of modern science, highlighting the potential therapeutic applications of traditional remedies.
3) Rudraksha (RudrÄkᚣa, Rudra-aksha):
Rudraksha refers to the seeds of the Elaeocarpus ganitrus tree, traditionally used in Ayurvedic medicine for various ailments. The extract from these seeds is central to this study, demonstrating potential antihypertensive effects. Its historical significance in holistic health boosts its relevance in contemporary scientific investigations.
4) Science (Scientific):
Scientific pertains to rigorous methodologies applied in research. This study adopts a scientific approach to validate the efficacy of Rudraksha extract in treating hypertension. By conducting controlled experiments and statistical analysis, it seeks to integrate traditional medicine into modern healthcare paradigms through evidence-based practices.
5) Water:
Water in this context is relevant for its role in the extraction process of Rudraksha. The study utilized a water-soluble portion of the ethanol extract to assess its effects on blood pressure. Water as a solvent exemplifies fundamental principles in pharmacology and influences the bioavailability of the drug.
6) Epilepsy:
Epilepsy is a neurological disorder marked by seizures. Traditional claims associate Rudraksha with therapeutic benefits in managing epilepsy, suggesting its multi-dimensional health effects. Investigating such claims through scientific exploration helps bridge cultural understandings of herbal medicine and offers insights into its potential roles in modern medical contexts.
7) Pharmacological:
Pharmacological relates to the study of drug effects on biological systems. This study examines the pharmacological properties of the Rudraksha extract in the context of hypertension, showcasing the importance of understanding drug actions, mechanisms, and interactions in both conventional and traditional medicinal applications.
8) Discussion:
Discussion is a critical component of research where results are interpreted and contextualized. In this study, the discussion section serves to analyze the findings regarding Rudraksha's effects on blood pressure, integrating them with existing literature. It facilitates a deeper understanding of implications for clinical practice and future research.
9) Activity:
Activity refers to the effectiveness of a substance in producing a desired response. In this study, the activity of the Rudraksha extract against hypertension is quantitatively assessed, allowing for evaluation of its therapeutic potential. Understanding the activity facilitates application in clinical settings and informs future investigations.
10) Fainting (Fainted):
Fainting, or syncope, involves a transient loss of consciousness due to reduced blood flow to the brain. Traditional medicine attributes benefits of Rudraksha to conditions like fainting. The connection between traditional claims and modern scientific study opens dialogue on therapeutic options for sudden health disturbances linked to blood pressure.
11) Incision:
Incision refers to a surgical cut made to perform medical procedures. The study involved making incisions to access the femoral vein for drug administration. Understanding surgical techniques and their implications enhances the methodological rigor of the study while underscoring the invasiveness of certain experimental approaches.
12) Sharman (Ĺarma, SarmÄ, Sarma, Sharma, Ĺarman):
Sarma, another contributor to the research, is credited for conducting experiments and offering insights into the study's findings. Mentioning authors reinforces the human element behind scientific discovery and emphasizes the collaborative efforts essential in validating traditional medicine through experimental research.
13) Glass:
Glass refers to the materials used in laboratory settings, particularly in the preparation and administration of extracts. In this study, glass cannulas were utilized for vital procedures like ventilation and drug administration, emphasizing the importance of using appropriate materials to ensure accuracy and safety in experimental methodologies.
14) Shri (Ĺri, ĹrÄŤ, Ĺáš�, Sáš�, Sáš�):
Shri is a respectful honorific used in Indian culture, often preceding a name. In the context of this study, it precedes the name of the CEO and reinforces the cultural significance of titles. Acknowledging such titles is essential in recognizing the contributions of individuals within collaborative research.
Other Science Concepts:
Discover the significance of concepts within the article: â�Evaluating rudraksha's effect on adrenaline and nicotine hypertension.â�. Further sources in the context of Science might help you critically compare this page with similair documents:
Statistical Significance, Experimental study, Cardiac Output, Mean blood pressure, Administration of drug, Hypertensive agents, Blood pressure measurement, Hypotensive effect, Adrenaline induced hypertension, Experimental hypertension.