Antitumor activity of Ludwigia prostrata against Dalton's lymphoma.
Journal name: Ancient Science of Life
Original article title: Antitumour activity of root extract of Ludwigia Prostrata Roxb. Against Dalton's Ascitic Lymphoma
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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A.M. Shanmugham, S. Balu, S. Kavimani
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Antitumour activity of root extract of Ludwigia Prostrata Roxb. Against Dalton's Ascitic Lymphoma
Year: 2000
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
The study investigates the antitumour activity of methanol extract from the roots of Ludwigia prostrata Roxb. against Dalton's Ascitic Lymphoma (DAL) in Swiss albino mice. This particular plant, which has not been thoroughly researched for its medicinal properties, belongs to the Onagraceae family. The results demonstrated a significant increase in the median survival time of treated mice compared to control groups, alongside alterations in hematological parameters, suggesting potential therapeutic benefits.
Impact on Survival Rates
The results indicated that treatment with root extract at two different doses (50 mg/kg and 100 mg/kg) increased the median survival time (MST) of tumour-bearing mice to 26 and 28 days, respectively, compared to 21 days in the control group treated with saline. Furthermore, the standard drug 5-Fluorouracil (5 FU), at a dose of 20 mg/kg, yielded an MST of 39 days, showcasing a greater efficacy. Hematological analyses revealed that the root extract notably improved red blood cell counts and decreased white blood cell counts, which is indicative of its potential as an anticancer agent, attributed possibly to the presence of flavonoids known for their anticarcinogenic effects.
Conclusion
The research underscores the potential of Ludwigia prostrata root extract as a viable antitumour treatment through its capability to prolong life in mice afflicted with DAL and fare well against standard chemotherapy agents. The study highlights the necessity for further research into the medicinal properties of this plant, with admiration for its promising effects and the need for exploring its biochemical constituents that contribute to its antitumour activity. These findings may lead to the development of alternative therapies for cancer management, particularly in the form of plant-derived compounds.
FAQ section (important questions/answers):
What was the aim of the study on Ludwigia prostrata?
The study aimed to investigate the antitumour activity of Ludwigia prostrata root extract against Dalton鈥檚 Ascitic Lymphoma in Swiss albino mice, specifically measuring its effectiveness in prolonging median survival time and affecting haematological parameters.
What methods were used to test the root extract's effectiveness?
Mice were inoculated with Dalton鈥檚 Ascitic Lymphoma cells and treated with different concentrations of the root extract. Median survival time and haematological parameters were evaluated after nine days of treatment to assess the extract's efficacy.
What were the key results regarding survival time from the study?
Mice treated with 50 mg/kg and 100 mg/kg root extract exhibited median survival times of 26 days and 28 days, respectively, compared to 21 days in control and 39 days for those treated with 5-Fluorouracil.
How did the root extract affect haematological parameters in mice?
The root extract treatment resulted in increased red blood cell counts and haemoglobin levels while reducing white blood cell counts, protein, and packed cellular volume, indicating a positive effect on the overall health of tumour-bearing mice.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for 鈥淎ntitumor activity of Ludwigia prostrata against Dalton's lymphoma.鈥�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Blood:
Blood is a vital fluid in the body, responsible for transporting oxygen, nutrients, and hormones to cells while removing waste products. In the context of the study, blood parameters such as red blood cell count and white blood cell count are crucial in evaluating the effects of Ludwigia prostrata extract as a potential anti-cancer treatment.
2) Drug:
A drug is a substance used to diagnose, cure, or prevent diseases. The research investigates the antitumour activity of the root extract of Ludwigia prostrata, exploring its efficacy compared to standard anti-cancer drug 5-Fluorouracil, providing insights into alternative herbal therapies in cancer treatment.
3) Activity:
In scientific studies, 'activity' often pertains to the biological or pharmacological effects of a substance. The antitumour activity of the Ludwigia prostrata root extract was measured by observing changes in median survival time and hematological parameters in tumor-bearing mice, demonstrating its potential therapeutic effects.
4) Cancer:
Cancer is a group of diseases characterized by unregulated cell growth. The study focuses on Dalton's Ascitic Lymphoma, a type of cancer in mice. Understanding the mechanisms and treatments for cancer is essential for developing effective therapies, including herbal remedies such as Ludwigia prostrata.
5) Science (Scientific):
Science refers to a systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions about the universe. In this study, scientific methods are applied to investigate the medicinal properties of Ludwigia prostrata and its potential antitumour effects through controlled experimentation.
6) Botany:
Botany is the scientific study of plants, including their structure, properties, and biochemical processes. The research is rooted in botany, examining the Ludwigia prostrata plant's properties and extracting its roots to evaluate their potential antitumour activity, thus highlighting the importance of plant science in medicine.
7) Antibiotic (Antibacterial):
Antibacterial substances fight against bacterial infections. Although the main focus of the study is antitumour activity, antibacterial properties of plant extracts can also be significant in pharmacological studies, offering a broader understanding of the medicinal potential of Ludwigia prostrata beyond just cancer treatment.
8) Phytochemical:
Phytochemicals are naturally occurring compounds found in plants known for their biological activity. The study involves phytochemical screening of Ludwigia prostrata to identify compounds responsible for its antitumour effect, which could include flavonoids, contributing to our understanding of plant-based therapeutic options.
9) Pharmacology:
Pharmacology is the branch of medicine that focuses on drug action and interactions with biological systems. This study contributes to pharmacology by exploring the effects of Ludwigia prostrata's root extract as a potential anticancer drug, advancing the understanding of herbal medicines in cancer therapy.
10) Discussion:
The discussion section in scientific studies analyzes findings and relates them to existing literature. This paper's discussion focuses on interpreting the antitumour efficacy of the Ludwigia prostrata root extract and situates it within the broader context of cancer research and treatment strategies.
11) Flavonoid:
Flavonoids are a class of plant secondary metabolites known for their antioxidant and potential anticarcinogenic properties. The study speculates that flavonoids in Ludwigia prostrata may contribute to its observed antitumour effects, underlining the significance of understanding plant compounds in developing cancer therapies.
12) Mahendra (M膩hendra, Mahemdra, Maha-indra):
Mahendra refers to an author cited in the references related to the flora of the presidency of Madras. Citing reputable sources in scientific literature reinforces the credibility of the study and situates the findings within established botanical and phytochemical knowledge bases.
13) Water:
Water is essential for life and plays critical roles in biological processes. In the study, mice were fed and hydrated with standard laboratory diet and water ad libitum, ensuring that all physiological variables are controlled while examining the effects of Ludwigia prostrata root extract.
14) Diet:
Diet refers to the types of food consumed by organisms, crucial in laboratory studies. In this experiment, mice were provided with a standard diet to minimize nutritional variability, ensuring accurate assessment of the antitumour activity of the Ludwigia prostrata root extract under controlled conditions.
Other Science Concepts:
Discover the significance of concepts within the article: 鈥�Antitumor activity of Ludwigia prostrata against Dalton's lymphoma.鈥�. Further sources in the context of Science might help you critically compare this page with similair documents:
Sodium chloride, Phytochemical screening, Animal model, 5-Fluorouracil, Ancient Science of life, White blood cell count, Haematological studies, Antitumour activity, Antimutagenic effect, Dalton's ascitic lymphoma, Increase in life span, Median survival time, Standard laboratory diet, Dose of Treatment, Cancer research institute, Anticarcinogenic effect.