In vitro studies on thyrogenic effect of commiphora mukul (guggulu)
Journal name: Ancient Science of Life
Original article title: In vitro studies on thyrogenic effect of commiphora mukul (guggulu)
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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A.K. Singh, G.C Prasad, S.N. Tripathi
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: In vitro studies on thyrogenic effect of commiphora mukul (guggulu)
Year: 1982
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
The study investigates the thyrogenic effects of Commiphora mukul (Guggulu) on thyroid gland activity through in vitro experimentation. The research focuses on the impact of this herb on various thyroid functions, particularly the I 131 uptake, T3 resin uptake, protein-bound iodine (PBI), and free thyroxine index, while also examining the interplay between Commiphora mukul and melatonin, a known inhibitor of thyroid function. The rationale for this study is rooted in previous findings that link thyroid functionality with lipoprotein metabolism and the well-established hypolipidemic effects of Commiphora mukul.
Enhancement of Thyroid Function through Commiphora Mukul
The results demonstrate a significant stimulatory effect of petroleum ether extract of Commiphora mukul on thyroid function. Cultured thyroid explants exhibited increased I 131 uptake, T3 resin uptake, and PBI levels, with the enhancements being dose-dependent and markedly pronounced at higher concentrations of C. mukul. In contrast, treatment with melatonin led to a significant depression in these parameters, implicating melatonin as an inhibitor of thyroid hormone activity. However, when thyroid explants were concurrently treated with both melatonin and C. mukul, the stimulatory effects of C. mukul effectively antagonized the depressive impacts of melatonin, suggesting a direct stimulatory action of C. mukul on thyroid cell function.
Conclusion
The findings of this study suggest that Commiphora mukul has a potential role in managing hypothyroidism and related disorders. The herb appears to directly enhance thyroid gland activity at the cellular level, improving hormone synthesis and secretion despite the presence of inhibitory factors like melatonin. Given the established link between thyroid dysfunction and conditions such as hypercholesterolemia, the results indicate that Commiphora mukul may offer therapeutic benefits in regulating thyroid hormone levels, thus contributing to the overall management of metabolic disturbances associated with hypothyroidism. Further research is warranted to elucidate the underlying mechanisms of action and its long-term effects in clinical settings.
FAQ section (important questions/answers):
What is the main focus of the study on Commiphora mukul?
The study investigates the thyrogenic effect of petroleum ether extract of Commiphora mukul on thyroid gland in vitro, revealing its potential to enhance thyroid hormone production and counteract the inhibitory effects of melatonin.
How does melatonin affect thyroid function in the study?
Melatonin treatment significantly decreases I 131 uptake, T 3 resin uptake, and free thyroxine index in thyroid explants, indicating that it suppresses thyroid hormone release and iodide accumulation.
What were the notable results of using C. mukul extract?
The use of petroleum ether extract of C. mukul significantly increased I 131 uptake, T 3 resin uptake, protein-bound iodine, and free thyroxine index, suggesting a stimulatory effect on thyroid function.
What implications does this study have for health conditions?
The findings suggest that Commiphora mukul may help manage hypothyroidism and associated disorders like hypercholesterolemia, potentially through direct stimulation of thyroid function.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “In vitro studies on thyrogenic effect of commiphora mukul (guggulu)�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
The term 'drug' refers to a substance used for medical purposes, in this context representing Commiphora mukul, which is a natural compound investigated for its therapeutic effects. The study focuses on its potential benefits in managing hypothyroidism and related disorders, showcasing the importance of drug research in health care.
2) Depression:
In this study, 'depression' highlights the reduction in thyroid function markers (I 131 uptake, T 3 resin uptake, etc.) due to certain treatments like melatonin. Understanding depression in these parameters is crucial for assessing thyroid functioning and the efficacy of treatments, such as those properties evident in Commiphora mukul.
3) Commiphora mukul:
Commiphora mukul, also known as Guggulu, is an herbal remedy investigated for its thyroid-stimulating effects. The research demonstrates its potential in enhancing thyroid function and addressing hypolipidemia, suggesting its significance in alternative medicine and endocrinology, especially related to conditions like hypothyroidism and associated metabolic disorders.
4) Activity:
The word 'activity' in the document refers to the biological effects induced by Commiphora mukul and melatonin on thyroid gland explants. Tracking activity through measurable data, such as hormone uptake, helps in understanding how interventions impact metabolic processes, paving the way for therapeutic applications in endocrine disorders.
5) Science (Scientific):
The term 'science' relates to the systematic study represented in the research paper, employing experimental methodologies to establish relationships between substances like Commiphora mukul and thyroid function. It underscores the framework of evidence-based practice in medicine and highlights the role of scientific investigations in developing effective treatments.
6) Accumulation (Accumulating, Accumulate):
In this context, 'accumulating' refers to the processes by which iodine and thyroid hormones are taken up by the thyroid gland. Understanding the mechanisms of accumulation is vital for assessing thyroid health, particularly in relation to the stimulating effects of Commiphora mukul and how they can counteract inhibitors like melatonin.
7) Discussion:
The 'discussion' section of the study synthesizes the findings and implications of the research. Here, the authors interpret results, connect them to existing literature, and elaborate on the potential mechanisms of action of Commiphora mukul, fostering deeper understanding in the scientific community about thyroid function modulation.
8) Guggulu:
Guggulu is a common name for Commiphora mukul, the focus of this study. Known for its medicinal properties, particularly in managing weight and cholesterol levels, Guggulu's relevance amplifies when discussing its role in hypothyroidism, highlighting traditional medicine's impact on modern clinical practices concerning thyroid health.
9) Mishra (Miśra):
Misra refers to S.K. Misra, one of the individuals acknowledged for their technical support in this research. Acknowledgments are essential in scholarly work, recognizing contributions that illicit expertise and support, fostering collaboration within scientific inquiry, and enhancing the quality and validity of experimental results.
10) Water:
While 'water' may refer indirectly to its role in biological systems as a medium in experiments, it is intrinsic to all cellular processes. In this context, the importance of maintaining appropriate chemical environments, such as moisture levels in in vitro studies of thyroid functions, underlines water's fundamental role in life sciences.
11) Eagle:
Though 'eagle' seems out of place, it could symbolize far-reaching insights and perspectives in scientific inquiry. Additionally, the term might connote precision in investigations, akin to an eagle's keen vision, which is crucial for discerning subtle effects of treatments like Commiphora mukul in thyroid hormone dynamics.
12) Hand:
'Hand' might refer to the manual processes involved in the experimental procedures. Accurate and careful handling of biological samples and data is crucial in laboratory research. It embodies the human element behind scientific exploration, emphasizing the operator's role in obtaining reliable and interpretable results in studies.
Other Science Concepts:
Discover the significance of concepts within the article: �In vitro studies on thyrogenic effect of commiphora mukul (guggulu)�. Further sources in the context of Science might help you critically compare this page with similair documents:
Commiphora mukul, Hypothyroidism management, In vitro studies, Petroleum ether extract, Hypolipidemic agent, Hypercholesterolemia, Lipoprotein metabolism, Culture media, Melatonin treatment, Dose-related increase.