Significance of Tumor microenvironment
The tumor microenvironment refers to the complex surroundings of a tumor, incorporating various cellular and extracellular elements such as stroma, blood vessels, signaling molecules, and immune cells. This environment significantly affects tumor progression, metastasis, and response to therapies. Factors like chemokines, inflammatory signals, and structural components all interact within this space, influencing cancer cell behavior and therapeutic effectiveness. Understanding the tumor microenvironment is crucial for developing targeted cancer treatments and improving therapeutic outcomes.
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The concept of Tumor microenvironment in scientific sources
The tumor microenvironment encompasses diverse cellular and extracellular components, such as chemokines and immune cells, that significantly impact tumor progression, growth, and metastasis, largely regulated by inflammatory cells.
From: The Malaysian Journal of Medical Sciences
(1) This is an environment where an improved knowledge of extra-chromosomal DNAs might allow for the rational design of molecules to block the pathological processes.[1] (2) Cell-free miRNA enables communication between cells within this, influencing tumor development.[2] (3) This is the area around the tumor, and the recruitment and activation of eosinophils towards this is a complex process.[3] (4) This is the local surroundings of the tumor, including stroma and extracellular matrix, where cancer cells interact and are influenced by various chemical and physical signals.[4] (5) The cellular environment surrounding a tumor, critical for cancer progression, influenced by immune cells and factors released during inflammation.[5]