Significance of Toxicity study
Toxicity studies are systematic evaluations that assess the safety and potential adverse effects of various substances, particularly in drug development. These assessments encompass a wide range of research involving both animal models and cell lines to determine the safety profiles and harmful impacts of compounds such as the Germanium-Hesperidin complex, Cissus quadrangularis, and other extracts. They play a crucial role in ensuring that substances are safe for therapeutic use, establishing their effects through controlled testing methodologies.
Synonyms: Safety assessment, Toxicity assessment, Toxicological study, Risk assessment, Toxicity evaluation, Safety study, Toxicological analysis
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Toxicity study in scientific sources
Toxicity study is a research evaluation focused on determining the safety and potential adverse effects of substances, such as Panchakola Avaleha, particularly through animal models and varying exposure levels.
From: World Journal of Pharmaceutical Research
(1) An experiment designed to evaluate the safety and potentially harmful effects of the test drug on animals.[1] (2) An assessment of the harmful effects of a substance on living organisms, typically evaluated to determine safety prior to use in medicinal applications.[2] (3) An investigation into the harmful effects of a substance, like the ethanolic extract of Parthenium hysterophorus, on rats, assessing blood biochemistry.[3] (4) Evaluation of potential harmful effects of a substance through controlled testing in animal models.[4] (5) An evaluation designed to assess the potential harmful effects of a substance, particularly focusing on its safety profile in experimental animals over a specified duration.[5]
From: International Ayurvedic Medical Journal
(1) An evaluation performed to assess the safety of the ethanolic extract of Entada pursaetha DC in Wistar rats, confirming no significant toxicity at a high dosage.[6] (2) An evaluation process to determine the safety and effect of a substance, such as hydroalcoholic extract of Mansoa alliacea, on animal health over a specified duration.[7] (3) An assessment to measure the safety and potential harmful effects of a drug on animals over a specified period.[8] (4) A systematic investigation assessing the safety profile of a substance, specifically measuring its potential harmful effects at various dosages.[9] (5) An examination focused on assessing the toxic effects of substances, in this context specifically pertaining to Gambhari Phala Churna.[10]
From: AYU (Journal of Research in Ayurveda)
(1) Research conducted to evaluate the adverse effects of a substance or formulation on living organisms.[11] (2) Research conducted to determine the effects of a substance at varying levels of exposure to ascertain safety and adverse effects.[12] (3) A research evaluation aimed at assessing the safety and potential adverse effects of a substance, in this case, the Panchakola Avaleha, particularly in animal models.[13]
From: Journal of Ayurveda and Integrative Medicine
(1) An assessment conducted to evaluate the toxic effects of Rasasindura and Kajjali on NIH3T3 cell lines and zebrafish larvae.[14] (2) A toxicity study involves assessing the potential harmful effects of substances on living organisms, specifically examining the safety profile of Tamra Bhasma in this context.[15] (3) An evaluation conducted to determine the safety profile and adverse effects of a substance, in this case, the alcoholic extract of Celastrus paniculatus.[16]
From: Ancient Science of Life
(1) An assessment conducted to evaluate the safety of ethanolic extracts of Nyctanthes arbortristis at varying doses in a controlled experimental setup.[17] (2) An investigation conducted to establish the safety aspects of Lauha Bhasma through acute and subacute testing in albino rats.[18]
From: Ayushdhara journal
(1) An experimental analysis conducted to assess the harmful effects and safety of a substance on living organisms.[19]