Significance of Tissue injury
Tissue injury refers to the damage incurred by living tissues, which can occur due to various factors, including oxidative stress, inflammation, and external injuries. It encompasses a range of conditions such as gastric mucosal damage from ethanol, kidney tissue damage from urolithiasis, and complications resulting from surgical procedures. Tissue injury triggers a healing response that involves inflammatory processes and the recruitment of stem cells or fibroblasts, highlighting its complexity and relevance in health and disease management.
Synonyms: Tissue damage, Cellular injury, Soft tissue injury, Lesion, Tissue trauma
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Tissue injury in scientific sources
Tissue injury involves damage to body tissues due to oxidative stress and free radicals, as well as biological damage from infections or trauma, potentially triggering an acute phase response in the body.
From: The Malaysian Journal of Medical Sciences
(1) Tissue injury is the target of inflammatory feedback, mediated by caspase-1, which is engaged in both the initiation of the inflammatory response and the induction of cell death.[1] (2) This is what the inflammatory response tries to minimize, which may be triggered by superficial damage to the gastric mucosa.[2] (3) This is the direct harm to the tissues, and is caused by the cascade of events initiated by radiotherapy and chemotherapy, which can lead to ulceration and other complications.[3] (4) Tissue injury can induce complex pathological processes that increase oxidative stress, inflammation, autophagy, apoptosis, and cellular senescence, which can further damage the kidney.[4] (5) These stem cells are thought to reside in a specific area of each tissue where they remain quiescent (non dividing) for many years until they are activated by disease or tissue injury.[5]