Significance of Senile plaques
Senile plaques are extracellular aggregates primarily composed of β-amyloid (Aβ) protein. They serve as a key hallmark of Alzheimer's disease, characterized by abnormal clusters of protein fragments that build up in the brains of affected individuals. These plaques disrupt cell function and interfere with neuron-to-neuron signaling, significantly contributing to the pathology of Alzheimer's disease. The accumulation of these β-amyloid clusters is a critical factor in the progression and symptoms associated with this neurodegenerative condition.
Synonyms: Beta-amyloid plaques, Neuritic plaques
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The concept of Senile plaques in scientific sources
Senile plaques are abnormal clusters of protein fragments found in the brains of Alzheimer's patients, leading to disrupted cellular function and contributing to the cognitive decline associated with the disease.
From: World Journal of Pharmaceutical Research
(1) Clusters of beta-amyloid fragments that accumulate outside neurons and disrupt neuron-to-neuron signaling, contributing to Alzheimer's disease pathology.[1] (2) Senile plaques are extracellular aggregates primarily made of β-amyloid (Aβ) protein and serve as a pathology hallmark in Alzheimer's disease.[2]
From: Ancient Science of Life
(1) Abnormal clusters of protein that accumulate in the brains of individuals with Alzheimer's disease and are thought to be pathogenic.[3]
From: International Ayurvedic Medical Journal
(1) Abnormal clusters of protein fragments that accumulate in the brains of people with Alzheimer's disease, disrupting cell function.[4]