Significance of Proliferation
Proliferation refers to the rapid increase in cell numbers, a crucial concept in various biological processes. In the context of cancer, Andrographolide plays a role by inhibiting the uncontrolled division of human lung cancer cells. Additionally, epithelial, fibroblast, and myofibroblast cell proliferation contribute to kidney fibrosis, along with apoptosis in damaged tubular cells. Moreover, the regulation of cell proliferation is influenced by miRNAs found in the extracellular vesicles of umbilical cord mesenchymal stem cells (UCMSCs).
Synonyms: Expansion, Increase, Multiplication, Growth, Spread, Propagation
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The concept of Proliferation in scientific sources
Proliferation pertains to the uncontrolled growth of cells, as seen in both kidney fibrosis through various cell types and in cancer cells, where inhibitors like andrographolide disrupt this excessive cellular division.
From: The Malaysian Journal of Medical Sciences
(1) This is the third phase of wound healing, involving the growth of new tissue, also known as granulation, and it follows inflammation, and it is followed by remodelling.[1] (2) This is the rapid increase in numbers, as the cells of ORL115 and ORL188 are inhibited by MTJ.[2] (3) This is the process of cell growth and division, and the effect of (R)-(�)-carvone on this process was evaluated.[3] (4) This is the rapid increase in numbers of cells, and is regulated by miRNAs in UCMSC's EVs.[4] (5) Epithelial, fibroblast, and myofibroblast cell proliferation are also part of the cellular processes driving kidney fibrosis, as well as apoptosis, which occurs in damaged tubular cells.[5]