Significance of Multidrug resistance
Multidrug resistance refers to the ability of bacteria and cancer cells to resist the effects of multiple antimicrobial agents and anticancer drugs, respectively. This phenomenon complicates treatment options and can lead to treatment failures. In bacteria, such as Mycobacterium tuberculosis and Pseudomonas aeruginosa, multidrug resistance often arises from genetic mutations or the presence of efflux pumps. In cancer cells, resistance can be mediated by overexpression of proteins, making it increasingly urgent to develop alternative therapies and strategies to combat these resistant strains.
Synonyms: Antimicrobial resistance, Drug resistance, Antibiotic resistance, Pharmacoresistance, Treatment resistance
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Multidrug resistance in scientific sources
Multidrug resistance is a significant public health challenge, where microorganisms evolve to withstand multiple drugs, complicating treatment efforts and increasing the risk of untreatable infections.
From: The Malaysian Journal of Medical Sciences
(1) This is the ability of bacteria to resist multiple antibiotics, which poses a significant challenge in treating infections and is a major concern.[1] (2) This signifies the ability of microorganisms to resist multiple antimicrobial drugs, a significant characteristic of certain bacterial strains, particularly in the context of Acinetobacter baumannii infections.[2] (3) Multidrug resistance is developed by TA modules in pathogenic bacteria, creating problems during the treatments of disease.[3] (4) This is the ability of a bacterial strain to resist the effects of multiple antibiotics, and it can be associated with specific SCCmec types in CoNS isolates.[4] (5) A phenomenon where microorganisms develop resistance to multiple types of drugs, often linked to specific plasmids carrying resistance genes.[5]