Significance of Micronuclei formation
Micronuclei formation is the creation of small additional nuclei in cells, which can indicate genetic instability, cellular damage, and potential cancer prognosis. This phenomenon occurs due to chromosomal damage, especially during cell division when fragments or whole chromosomes lag. It is analyzed in toxicology studies to assess genotoxicity, particularly in bone marrow cells, and can indicate the effects of heavy metal exposure or radiation. Overall, it serves as a valuable marker in understanding cellular damage and cancer diagnosis.
Synonyms: Micronucleus formation
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The concept of Micronuclei formation in scientific sources
Micronuclei formation involves the creation of small nuclei from chromosomal damage, signaling genotoxicity in bone marrow cells, often linked to chromosome fragments lagging in cell division due to heavy metal exposure.
From: The Malaysian Journal of Medical Sciences
(1) The creation of small, additional nuclei in cells resulting from radiation, linked to genetic instability and cancer prognosis.[1] (2) The creation of small nuclei that can indicate cellular damage or genotoxic stress, relevant in cancer diagnosis.[2] (3) The formation of small nuclei that can indicate cellular damage or genotoxicity, often assessed in toxicology studies.[3]