Significance of Hepatic fibrosis
Hepatic fibrosis is the condition characterized by the thickening and scarring of liver tissue due to chronic liver injury, often seen in conditions like alcoholic liver disease (ALD). It involves excessive accumulation of extracellular matrix proteins, leading to potential outcomes such as cirrhosis and liver cancer. This progressive scarring impairs liver function and results from ongoing damage and inflammation. Treatment approaches, such as quercetin and BM-MSC therapy, aim to modulate these cellular processes and alleviate the effects of hepatic fibrosis.
Synonyms: Liver fibrosis
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The concept of Hepatic fibrosis in scientific sources
Hepatic fibrosis is the excessive buildup of extracellular matrix proteins in the liver due to chronic injury, leading to potential cirrhosis and cancer. It involves a wound-healing response, with quercetin potentially mitigating tissue thickening and scarring.
From: The Malaysian Journal of Medical Sciences
(1) This refers to the scarring of the liver, which can be a consequence of hepatic cellular injury, and is linked to excessive fructose consumption.[1] (2) The excessive and disorganized accumulation of extracellular matrix components in the liver, which can lead to loss of normal liver function.[2]