Significance of Genetic heterogeneity
Genetic heterogeneity refers to the variation in genetic makeup among individuals within a condition or natural populations. This concept complicates the understanding of disorders like otosclerosis and affects the pathogenicity of strains such as Staphylococcus aureus. It highlights the considerable genetic diversity present in these populations and is driven by factors like extrachromosomal oncogene amplification in tumors. Additionally, it complicates diagnosis and treatment in conditions like congenital dyserythropoietic anemia and indicates variability among Vibrio vulnificus strains in different environments.
Synonyms: Genetic diversity, Genetic variation, Genetic polymorphism, Genetic variability, Genetic differences
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Genetic heterogeneity in scientific sources
Genetic heterogeneity encompasses the variation in genetic makeup among individuals, complicating conditions like otosclerosis, and also highlights the diverse genetic characteristics in Staphylococcus aureus populations, influencing their pathogenicity.
From: The Malaysian Journal of Medical Sciences
(1) This refers to the variation in genetic makeup, specifically within the context of acute myeloid leukemia, which contributes to the disease's complexity and challenges in treatment.[1] (2) This is a concept that is at least partly responsible for the differences in how the disorder manifests, which is an important implication of models that involve multiple genetic and environmental factors.[2] (3) Genetic heterogeneity is a diversity that is driven by extrachromosomal oncogene amplification during tumor evolution, as indicated in the given text.[3] (4) Variability in the genetic makeup among the Vibrio vulnificus strains, indicating diverse strains present in different environmental conditions.[4]