Significance of G1 cell cycle arrest
G1 cell cycle arrest refers to the halting of the cell cycle at the G1 phase, a process influenced by compounds such as Marmelin, which can induce apoptosis in cancer cells. Additionally, extracts from A. muricata have shown potential to induce G1 cell cycle arrest, effectively blocking cancer cell progression. This highlights the significance of targeting the G1 phase in cancer therapies to inhibit tumor growth and promote cell death.
Synonyms: G1 phase arrest
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The concept of G1 cell cycle arrest in scientific sources
G1 cell cycle arrest involves stopping the cell cycle at the G1 phase, which compounds like Marmelin can induce to trigger apoptosis in cancer cells. A. muricata extracts also show potential to block cancer cell progression.
From: The Malaysian Journal of Medical Sciences
(1) G1 cell-cycle arrest is a process in which the p16 plays a pivotal role by activation of the retinoblastoma tumor suppressor protein (pRb) in cellular senescence.[1] (2) This is a state that A. muricata extracts were shown to have the potential to induce, potentially blocking the cell cycle progression in cancer cells.[2]