Significance of Executioner caspases
Executioner caspases are crucial proteins that directly facilitate the process of apoptosis, the programmed cell death. Their levels increase in response to various signals that activate the apoptotic pathway. Indicators of this activation include heightened production of reactive oxygen species (ROS), detectable levels of cytochrome c, and elevated amounts of both initiator and executioner caspases in different cell lines. This suggests that executioner caspases play a significant role in the regulation of apoptosis.
Synonyms: Caspase-3, Effector caspases
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The concept of Executioner caspases in scientific sources
Executioner caspases are crucial in the apoptosis process, activated by increased levels of reactive oxygen species (ROS) and cytochrome c. They indicate apoptotic pathway activation in tested cell lines, alongside initiator caspases.
From: The Malaysian Journal of Medical Sciences
(1) These are caspases whose increase suggested the activation of the apoptotic pathway, as suggested by an increase in the production of ROS, an increase in detectable cytochrome c, and an increase in initiator and executioner caspases in both of the tested cell lines.[1]