Significance of D-dimer
D-dimer is a fibrin breakdown product that serves as a key marker for thrombotic activity and is used to assess blood clot formation and dissolution in various medical conditions. It is particularly relevant in diagnosing deep vein thrombosis and is notably elevated in COVID-19 patients, indicating disease severity and potential mortality risk. Additionally, D-dimer levels can provide insights into clot lysis activity and are valuable in evaluating thrombotic diseases and inflammation.
Synonyms: Fibrin degradation product, D-dimer test, D-dimer assay
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The concept of D-dimer in scientific sources
D-dimer is a fibrin degradation product essential for assessing clot formation and breakdown, serving as a biomarker for diagnosing conditions like disseminated intravascular coagulation (DIC) and evaluating thrombotic events and inflammation.
From: The Malaysian Journal of Medical Sciences
(1) A fibrin degradation product, used to help diagnose conditions where blood clots may be present, such as disseminated intravascular coagulation, and the levels observed in COVID-19 patients are secondary to systemic inflammation.[1] (2) A parameter frequently analyzed in haematology laboratories, it serves as a biomarker indicating coagulation activation and fibrinolysis, and is a product of fibrin degradation, used to identify blood clot formation.[2] (3) This is a screening tool used in the diagnosis of deep vein thrombosis, and is a test used after surgery to screen patients.[3]