Significance of Cleft lip and palate
Cleft lip and palate (CLP) is a significant public health issue occurring in about one in every 500 to 1000 births globally. It represents the most common orofacial congenital malformation, resulting from the failure of mid-facial skeletal components to fuse. This condition involves openings or splits in the upper lip and/or roof of the mouth, leading to various aesthetic, functional, and health complications. Treatment often requires a multidisciplinary approach due to its varying severity and potential associated deformities.
Synonyms: Cleft lip, Cleft palate
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Cleft lip and palate in scientific sources
Cleft lip and palate is a prevalent congenital facial malformation caused by the failure of palatal processes to fuse, affecting individuals across races and genders, making it one of the most common birth defects.
From: The Malaysian Journal of Medical Sciences
(1) This condition is the subject of genetic studies, looking at candidate genes in Japanese people and the role of genes such as MSX1 and TGFb3, and the effects of MTHFR polymorphism.[1] (2) A congenital condition characterized by an opening in the lip and/or the roof of the mouth, which may require specialized dental treatment.[2] (3) Cleft lip and palate (CLP) is the most common orofacial congenital malformation in live births, which can occur individually or in combination with other congenital deformities.[3] (4) Congenital craniofacial anomalies that occur when embryonic facial processes fail to unite, leading to complications such as malocclusion.[4] (5) Cleft lip and palate (CLP) occurs due to a failure of the skeletal components of the mid-face to fuse, representing the most common congenital abnormality.[5]