Significance of Cell cycle progression
Cell cycle progression is a crucial process that encompasses a series of events leading to cell division and replication. It is regulated by factors such as Akt and involves phases that can be influenced by metabolic processes and the dysregulation of proteins like Cyclin B1. Research indicates that blocking cell cycle progression in cancer cells can enhance the effectiveness of natural products, as shown with A. muricata extracts, which have demonstrated potential in inducing G1 cell cycle arrest.
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The concept of Cell cycle progression in scientific sources
Cell cycle progression involves a series of events leading to cell division and replication, significantly regulated by Akt, which plays a crucial role in promoting cellular growth and ensuring proper cell cycle advancement.
From: The Malaysian Journal of Medical Sciences
(1) This is the ordered sequence of events that lead to cell division, and can be disrupted by bacterial toxins, such as cytolethal distending toxin.[1] (2) Cyclin B1 is important for this process and is often dysregulated in gliomas, as described within the provided text.[2] (3) This is the ordered series of events that lead to cell growth and division, and CUL1 is involved in the regulation of this process.[3] (4) The ability to block this in cancer cells can effectively elevate the anti-cancer potential of natural products, and A. muricata extracts were shown to have the potential to induce G1 cell cycle arrest.[4]