Significance of Bcl-2
Bcl-2 is an anti-apoptotic protein crucial for regulating cell survival by preventing apoptosis. Its levels significantly influence cell death and proliferation, particularly in kidney tissues and muscles during aging. Decreased Bcl-2 expression correlates with increased apoptosis, as seen in rat liver studies and varies in comparison to pro-apoptotic proteins like Bax in patients with specific genetic profiles. Additionally, Bcl-2's role is notable in gliomas' aggressiveness and can be affected by compounds such as grape seed extract.
Synonyms: B-cell lymphoma 2, Anti-apoptotic protein, Oncoprotein
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The concept of Bcl-2 in scientific sources
Bcl-2 is an essential anti-apoptotic protein linked to decreased gene expression, leading to increased apoptosis, particularly in rat liver after aspartame exposure, while grape seed extract is noted for suppressing Bcl-2 to enhance apoptosis.
From: The Malaysian Journal of Medical Sciences
(1) The level of Bax (a pro-apoptotic protein) expression was significantly higher than that of Bcl-2 (an anti-apoptotic protein) in patients carrying the G allele, according to the results.[1] (2) Bcl-2 is an anti-apoptotic protein whose expression was compared to Bax in tumor cells and endothelial cells, and its expression in tumor cells correlated with tumor characteristics.[2] (3) This is a component of gliomas’ aggressiveness, which can be inhibited by some miRNAs.[3] (4) Bcl-2 is an anti-apoptotic protein that helps regulate cell survival by preventing apoptosis, and its levels can influence cell death versus proliferation in kidney tissues.[4]